An acute exposure to intermittent negative airway pressure elicits respiratory long-term facilitation in awake humans

Harry Griffin; Shoug Yousef Y Al Humoud; Joshua Benson; Brendan Cooper; Kristian Coomaraswamy; George Balanos

doi:10.1016/j.resp.2019.05.016

An acute exposure to intermittent negative airway pressure elicits respiratory long-term facilitation in awake humans

Harry Griffin, Shoug Yousef Y Al Humoud, Joshua Benson, Brendan Cooper, Kristian Coomaraswamy, George Balanos

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Abstract

BACKGROUND: A sustained elevation in respiratory drive following removal of the inducing stimulus is known as respiratory long-term facilitation (rLTF). We investigated whether an acute exposure to intermittent negative airway pressure (INAP) elicits rLTF in humans.

METHOD: 13 healthy males (20.9 ± 2.8 years) undertook two trials (INAP and Control). In the INAP trial participants were exposed to one hour of 30-second episodes of breathing against negative pressure (-10 cmH2O) interspersed by 60-second intervals of breathing at atmospheric pressure. In the Control trial participants breathed at atmospheric pressure for one hour. Ventilation following INAP (recovery phase) was compared to that during baseline.

RESULTS: Ventilation increased from baseline to recovery in the INAP trial (14.9 ± 0.9 vs 19.1 ± 0.7 L/min, P = 0.002). This increase was significantly greater than the equivalent during the Control trial (P = 0.019). Data shown as mean ± SEM.

CONCLUSION: In this study INAP elicited rLTF in awake, healthy humans. Further research is required to investigate the responsible mechanisms.

Original language	English
Pages (from-to)	20-26
Number of pages	7
Journal	Respiratory physiology & neurobiology
Volume	267
Early online date	6 Jun 2019
DOIs	https://doi.org/10.1016/j.resp.2019.05.016
Publication status	Published - 1 Sept 2019

Keywords

Intermittent negative airway pressure
Long-term facilitation

ASJC Scopus subject areas

Physiology
Neuroscience(all)
Pulmonary and Respiratory Medicine

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Griffin_et_al_An_acute_exposure_to_intermittent_negative_airway_pressure_elicits_respiratory_long-term_facilitation_in_awake_humans_Respiratory_physiology_&_neurobiology_2019
Checked for eligibility: 09/10/2019
Accepted author manuscript, 198 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

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title = "An acute exposure to intermittent negative airway pressure elicits respiratory long-term facilitation in awake humans",

abstract = "BACKGROUND: A sustained elevation in respiratory drive following removal of the inducing stimulus is known as respiratory long-term facilitation (rLTF). We investigated whether an acute exposure to intermittent negative airway pressure (INAP) elicits rLTF in humans.METHOD: 13 healthy males (20.9 ± 2.8 years) undertook two trials (INAP and Control). In the INAP trial participants were exposed to one hour of 30-second episodes of breathing against negative pressure (-10 cmH2O) interspersed by 60-second intervals of breathing at atmospheric pressure. In the Control trial participants breathed at atmospheric pressure for one hour. Ventilation following INAP (recovery phase) was compared to that during baseline.RESULTS: Ventilation increased from baseline to recovery in the INAP trial (14.9 ± 0.9 vs 19.1 ± 0.7 L/min, P = 0.002). This increase was significantly greater than the equivalent during the Control trial (P = 0.019). Data shown as mean ± SEM.CONCLUSION: In this study INAP elicited rLTF in awake, healthy humans. Further research is required to investigate the responsible mechanisms.",

keywords = "Intermittent negative airway pressure, Long-term facilitation",

author = "Harry Griffin and {Al Humoud}, {Shoug Yousef Y} and Joshua Benson and Brendan Cooper and Kristian Coomaraswamy and George Balanos",

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AU - Griffin, Harry

AU - Al Humoud, Shoug Yousef Y

AU - Benson, Joshua

AU - Cooper, Brendan

AU - Coomaraswamy, Kristian

AU - Balanos, George

PY - 2019/9/1

Y1 - 2019/9/1

N2 - BACKGROUND: A sustained elevation in respiratory drive following removal of the inducing stimulus is known as respiratory long-term facilitation (rLTF). We investigated whether an acute exposure to intermittent negative airway pressure (INAP) elicits rLTF in humans.METHOD: 13 healthy males (20.9 ± 2.8 years) undertook two trials (INAP and Control). In the INAP trial participants were exposed to one hour of 30-second episodes of breathing against negative pressure (-10 cmH2O) interspersed by 60-second intervals of breathing at atmospheric pressure. In the Control trial participants breathed at atmospheric pressure for one hour. Ventilation following INAP (recovery phase) was compared to that during baseline.RESULTS: Ventilation increased from baseline to recovery in the INAP trial (14.9 ± 0.9 vs 19.1 ± 0.7 L/min, P = 0.002). This increase was significantly greater than the equivalent during the Control trial (P = 0.019). Data shown as mean ± SEM.CONCLUSION: In this study INAP elicited rLTF in awake, healthy humans. Further research is required to investigate the responsible mechanisms.

AB - BACKGROUND: A sustained elevation in respiratory drive following removal of the inducing stimulus is known as respiratory long-term facilitation (rLTF). We investigated whether an acute exposure to intermittent negative airway pressure (INAP) elicits rLTF in humans.METHOD: 13 healthy males (20.9 ± 2.8 years) undertook two trials (INAP and Control). In the INAP trial participants were exposed to one hour of 30-second episodes of breathing against negative pressure (-10 cmH2O) interspersed by 60-second intervals of breathing at atmospheric pressure. In the Control trial participants breathed at atmospheric pressure for one hour. Ventilation following INAP (recovery phase) was compared to that during baseline.RESULTS: Ventilation increased from baseline to recovery in the INAP trial (14.9 ± 0.9 vs 19.1 ± 0.7 L/min, P = 0.002). This increase was significantly greater than the equivalent during the Control trial (P = 0.019). Data shown as mean ± SEM.CONCLUSION: In this study INAP elicited rLTF in awake, healthy humans. Further research is required to investigate the responsible mechanisms.

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KW - Long-term facilitation

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An acute exposure to intermittent negative airway pressure elicits respiratory long-term facilitation in awake humans

Abstract

Keywords

ASJC Scopus subject areas

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