An abundance of bacterial ADP-ribosyltransferases - implications for the origin of exotoxins and their human homologues

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Colleges, School and Institutes


ADP-ribosylation is a post-translational modification that can be seen in many contexts, including as the primary mechanism of action of many important bacterial exotoxins, By data-mining complete and incomplete bacterial genome sequences, we have discovered > 20 novel putative ADP-ribosyltransferases. including several new potential toxins.


Original languageEnglish
Pages (from-to)302-7
Number of pages6
JournalTrends in Microbiology
Issue number7
Publication statusPublished - 1 Jul 2001