Amygdala response to preattentive masked fear in children with conduct problems: The role of callous-unemotional traits

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Amygdala response to preattentive masked fear in children with conduct problems : The role of callous-unemotional traits. / Viding, E.; Sebastian, C.L.; Dadds, M.R.; Lockwood, P.L.; Cecil, C.A.M.; De Brito, S.A.; McCrory, E.J.

In: American Journal of Psychiatry, Vol. 169, No. 10, 01.10.2012, p. 1109-1116.

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Viding, E. ; Sebastian, C.L. ; Dadds, M.R. ; Lockwood, P.L. ; Cecil, C.A.M. ; De Brito, S.A. ; McCrory, E.J. / Amygdala response to preattentive masked fear in children with conduct problems : The role of callous-unemotional traits. In: American Journal of Psychiatry. 2012 ; Vol. 169, No. 10. pp. 1109-1116.

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@article{40d172b1080c4db78bf60f7c1d153e5a,
title = "Amygdala response to preattentive masked fear in children with conduct problems: The role of callous-unemotional traits",
abstract = "Objective: In children with conduct problems, high levels of callous-unemotional traits are associated with amygdala hypoactivity to consciously perceived fear, while low levels of callous-unemotional traits may be associated with amygdala hyperactivity. Behavioral data suggest that fear processing deficits in children with high callous-unemotional traits may extend to stimuli presented below conscious awareness (preattentively). The authors investigated the neural basis of this effect. Amygdala involvement was predicted on the basis of its role in preattentive affective processing in healthy adults and its dysfunction in previous studies of conduct problems. Method: Functional MRI was used to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed by backward masking) in boys with conduct problems and high callous-unemotional traits (N=15), conduct problems and low callous-unemotional traits (N=15), and typically developing comparison boys (N=16). Amygdala response to fearful and calm faces was predicted to differentiate groups, with the greatest response in boys with conduct problems and low callous-unemotional traits and the lowest in boys with conduct problems and high callous-unemotional traits. Results: In the right amygdala, a greater amygdala response was seen in boys with conduct problems and low callous-unemotional traits than in those with high callous-unemotional traits. The findings were not explained by symptom levels of conduct disorder, attention-deficit hyperactivity disorder, anxiety, or depression. Conclusions: These data demonstrate differential amygdala activity to preattentively presented fear in children with conduct problems grouped by callous-unemotional traits, with high levels associated with lower amygdala reactivity. The study's findings complement increasing evidence suggesting that callous-unemotional traits are an important specifier in the classification of children with conduct problems.",
author = "E. Viding and C.L. Sebastian and M.R. Dadds and P.L. Lockwood and C.A.M. Cecil and {De Brito}, S.A. and E.J. McCrory",
note = "Copyright 2012 Elsevier B.V., All rights reserved.",
year = "2012",
month = oct,
day = "1",
doi = "10.1176/appi.ajp.2012.12020191",
language = "English",
volume = "169",
pages = "1109--1116",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Publishing",
number = "10",

}

RIS

TY - JOUR

T1 - Amygdala response to preattentive masked fear in children with conduct problems

T2 - The role of callous-unemotional traits

AU - Viding, E.

AU - Sebastian, C.L.

AU - Dadds, M.R.

AU - Lockwood, P.L.

AU - Cecil, C.A.M.

AU - De Brito, S.A.

AU - McCrory, E.J.

N1 - Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Objective: In children with conduct problems, high levels of callous-unemotional traits are associated with amygdala hypoactivity to consciously perceived fear, while low levels of callous-unemotional traits may be associated with amygdala hyperactivity. Behavioral data suggest that fear processing deficits in children with high callous-unemotional traits may extend to stimuli presented below conscious awareness (preattentively). The authors investigated the neural basis of this effect. Amygdala involvement was predicted on the basis of its role in preattentive affective processing in healthy adults and its dysfunction in previous studies of conduct problems. Method: Functional MRI was used to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed by backward masking) in boys with conduct problems and high callous-unemotional traits (N=15), conduct problems and low callous-unemotional traits (N=15), and typically developing comparison boys (N=16). Amygdala response to fearful and calm faces was predicted to differentiate groups, with the greatest response in boys with conduct problems and low callous-unemotional traits and the lowest in boys with conduct problems and high callous-unemotional traits. Results: In the right amygdala, a greater amygdala response was seen in boys with conduct problems and low callous-unemotional traits than in those with high callous-unemotional traits. The findings were not explained by symptom levels of conduct disorder, attention-deficit hyperactivity disorder, anxiety, or depression. Conclusions: These data demonstrate differential amygdala activity to preattentively presented fear in children with conduct problems grouped by callous-unemotional traits, with high levels associated with lower amygdala reactivity. The study's findings complement increasing evidence suggesting that callous-unemotional traits are an important specifier in the classification of children with conduct problems.

AB - Objective: In children with conduct problems, high levels of callous-unemotional traits are associated with amygdala hypoactivity to consciously perceived fear, while low levels of callous-unemotional traits may be associated with amygdala hyperactivity. Behavioral data suggest that fear processing deficits in children with high callous-unemotional traits may extend to stimuli presented below conscious awareness (preattentively). The authors investigated the neural basis of this effect. Amygdala involvement was predicted on the basis of its role in preattentive affective processing in healthy adults and its dysfunction in previous studies of conduct problems. Method: Functional MRI was used to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed by backward masking) in boys with conduct problems and high callous-unemotional traits (N=15), conduct problems and low callous-unemotional traits (N=15), and typically developing comparison boys (N=16). Amygdala response to fearful and calm faces was predicted to differentiate groups, with the greatest response in boys with conduct problems and low callous-unemotional traits and the lowest in boys with conduct problems and high callous-unemotional traits. Results: In the right amygdala, a greater amygdala response was seen in boys with conduct problems and low callous-unemotional traits than in those with high callous-unemotional traits. The findings were not explained by symptom levels of conduct disorder, attention-deficit hyperactivity disorder, anxiety, or depression. Conclusions: These data demonstrate differential amygdala activity to preattentively presented fear in children with conduct problems grouped by callous-unemotional traits, with high levels associated with lower amygdala reactivity. The study's findings complement increasing evidence suggesting that callous-unemotional traits are an important specifier in the classification of children with conduct problems.

UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84867091559&md5=ffba9a48dc10c9e9484def3856ba7e97

U2 - 10.1176/appi.ajp.2012.12020191

DO - 10.1176/appi.ajp.2012.12020191

M3 - Article

AN - SCOPUS:84867091559

VL - 169

SP - 1109

EP - 1116

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 10

ER -