Amphiphilic block copolymer self-assemblies of poly(NVP)-b-poly(MDO-co-vinyl esters): tunable dimensions and functionalities

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Amphiphilic block copolymer self-assemblies of poly(NVP)-b-poly(MDO-co-vinyl esters) : tunable dimensions and functionalities. / Hedir, Guillaume G.; Pitto-Barry, A.; Dove, Andrew P.; O'Reilly, Rachel K.

In: Journal of Polymer Science. Part A: Polymer Chemistry, Vol. 53, No. 23, 01.12.2015, p. 2699-2710.

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@article{de45e9e63ce346d196519586b71a4002,
title = "Amphiphilic block copolymer self-assemblies of poly(NVP)-b-poly(MDO-co-vinyl esters): tunable dimensions and functionalities",
abstract = "Functional, degradable polymers were synthesized via the copolymerization of vinyl acetate (VAc) and 2‐methylene‐1,3‐dioxepane (MDO) using a macro‐xanthate CTA, poly(N‐vinylpyrrolidone), resulting in the formation of amphiphilic block copolymers of poly(NVP)‐b‐poly(MDO‐co‐VAc). The behavior of the block copolymers in water was investigated and resulted in the formation of self‐assembled nanoparticles containing a hydrophobic core and a hydrophilic corona. The size of the resultant nanoparticles was able to be tuned with variation of the hydrophilic and hydrophobic segments of the core and corona by changing the incorporation of the macro‐CTA as well as the monomer composition in the copolymers, as observed by Dynamic Light Scattering, Static Light Scattering, and Transmission Electron Microscopy analyses. The concept was further applied to a VAc derivative monomer, vinyl bromobutanoate, to incorporate further functionalities such as fluorescent dithiomaleimide groups throughout the polymer backbone using azidation and “click” chemistry as postpolymerization tools to create fluorescently labeled nanoparticles.",
keywords = "block copolymers, cyclic ketene acetal, degradable, nanoparticles, self-assembly",
author = "Hedir, {Guillaume G.} and A. Pitto-Barry and Dove, {Andrew P.} and O'Reilly, {Rachel K.}",
year = "2015",
month = dec,
day = "1",
doi = "10.1002/pola.27915",
language = "English",
volume = "53",
pages = "2699--2710",
journal = "Journal of Polymer Science. Part A: Polymer Chemistry",
issn = "0887-624X",
publisher = "Wiley",
number = "23",

}

RIS

TY - JOUR

T1 - Amphiphilic block copolymer self-assemblies of poly(NVP)-b-poly(MDO-co-vinyl esters)

T2 - tunable dimensions and functionalities

AU - Hedir, Guillaume G.

AU - Pitto-Barry, A.

AU - Dove, Andrew P.

AU - O'Reilly, Rachel K.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Functional, degradable polymers were synthesized via the copolymerization of vinyl acetate (VAc) and 2‐methylene‐1,3‐dioxepane (MDO) using a macro‐xanthate CTA, poly(N‐vinylpyrrolidone), resulting in the formation of amphiphilic block copolymers of poly(NVP)‐b‐poly(MDO‐co‐VAc). The behavior of the block copolymers in water was investigated and resulted in the formation of self‐assembled nanoparticles containing a hydrophobic core and a hydrophilic corona. The size of the resultant nanoparticles was able to be tuned with variation of the hydrophilic and hydrophobic segments of the core and corona by changing the incorporation of the macro‐CTA as well as the monomer composition in the copolymers, as observed by Dynamic Light Scattering, Static Light Scattering, and Transmission Electron Microscopy analyses. The concept was further applied to a VAc derivative monomer, vinyl bromobutanoate, to incorporate further functionalities such as fluorescent dithiomaleimide groups throughout the polymer backbone using azidation and “click” chemistry as postpolymerization tools to create fluorescently labeled nanoparticles.

AB - Functional, degradable polymers were synthesized via the copolymerization of vinyl acetate (VAc) and 2‐methylene‐1,3‐dioxepane (MDO) using a macro‐xanthate CTA, poly(N‐vinylpyrrolidone), resulting in the formation of amphiphilic block copolymers of poly(NVP)‐b‐poly(MDO‐co‐VAc). The behavior of the block copolymers in water was investigated and resulted in the formation of self‐assembled nanoparticles containing a hydrophobic core and a hydrophilic corona. The size of the resultant nanoparticles was able to be tuned with variation of the hydrophilic and hydrophobic segments of the core and corona by changing the incorporation of the macro‐CTA as well as the monomer composition in the copolymers, as observed by Dynamic Light Scattering, Static Light Scattering, and Transmission Electron Microscopy analyses. The concept was further applied to a VAc derivative monomer, vinyl bromobutanoate, to incorporate further functionalities such as fluorescent dithiomaleimide groups throughout the polymer backbone using azidation and “click” chemistry as postpolymerization tools to create fluorescently labeled nanoparticles.

KW - block copolymers

KW - cyclic ketene acetal

KW - degradable

KW - nanoparticles

KW - self-assembly

UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363445500004&KeyUID=WOS:000363445500004

U2 - 10.1002/pola.27915

DO - 10.1002/pola.27915

M3 - Article

VL - 53

SP - 2699

EP - 2710

JO - Journal of Polymer Science. Part A: Polymer Chemistry

JF - Journal of Polymer Science. Part A: Polymer Chemistry

SN - 0887-624X

IS - 23

ER -