AMP- and stress-activated protein kinases: key regulators of glucose-dependent gene transcription in mammalian cells?
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
- University of Bristol
This article will discuss the role of two classes of serine/threonine protein kinases in the regulation of gene transcription in mammals. The first is AMP-activated protein kinase (AMPK), which is responsive to changes in the intracellular energy status. The second is the 'stress-activated" family of protein kinases, members of the mitogen-activated protein (MAP) kinase superfamily, whose regulation by a number of extracellular agents (including osmotic stresses, cytokines, and heat) is less well understood. Interest in these enzymes has grown in the past few years due to mounting evidence (both pharmacological and genetic) which has implicated them in the regulation of a number genes important in mammalian metabolism.
|Number of pages||22|
|Journal||Progress in nucleic acid research and molecular biology|
|Publication status||Published - 2002|
- AMP-Activated Protein Kinases, Animals, Gene Expression Regulation, Glucose/metabolism, Humans, Insulin, Islets of Langerhans/metabolism, Liver/metabolism, Mitogen-Activated Protein Kinases/metabolism, Multienzyme Complexes/metabolism, Muscle, Skeletal/metabolism, Proinsulin/genetics, Protein Precursors/genetics, Protein-Serine-Threonine Kinases/metabolism, Saccharomyces cerevisiae/genetics