Altered cortical thickness following prenatal sodium valproate exposure

Amanda G. Wood; Jian Chen; Sarah Barton; Caroline Nadebaum; Vicki A. Anderson; Cathy Catroppa; David C. Reutens; Terence J. O'brien; Frank Vajda

doi:10.1002/acn3.74

Altered cortical thickness following prenatal sodium valproate exposure

Amanda G. Wood, Jian Chen, Sarah Barton, Caroline Nadebaum, Vicki A. Anderson, Cathy Catroppa, David C. Reutens, Terence J. O'brien, Frank Vajda

Psychology

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Abstract

Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.

Original language	English
Pages (from-to)	497-501
Journal	Annals of Clinical and Translational Neurology
Volume	1
Issue number	7
Early online date	3 Jul 2014
DOIs	https://doi.org/10.1002/acn3.74
Publication status	Published - 25 Jul 2014

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Wood_Altered_cortical_thickness_Annals_Clinical_Translational_Neurology_2014
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http://doi.wiley.com/10.1002/acn3.74

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title = "Altered cortical thickness following prenatal sodium valproate exposure",

abstract = "Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.",

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T1 - Altered cortical thickness following prenatal sodium valproate exposure

AU - Wood, Amanda G.

AU - Chen, Jian

AU - Barton, Sarah

AU - Nadebaum, Caroline

AU - Anderson, Vicki A.

AU - Catroppa, Cathy

AU - Reutens, David C.

AU - O'brien, Terence J.

AU - Vajda, Frank

PY - 2014/7/25

Y1 - 2014/7/25

N2 - Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.

AB - Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.

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DO - 10.1002/acn3.74

M3 - Article

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VL - 1

SP - 497

EP - 501

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 7

ER -

Altered cortical thickness following prenatal sodium valproate exposure

Abstract

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