Altered cortical thickness following prenatal sodium valproate exposure
Research output: Contribution to journal › Article
Colleges, School and Institutes
- The University of Melbourne, Parkville VIC 3010, Australia
- Southern Clinical School, Monash University, Clayton, Australia.
- Murdoch Childrens Research Institute; Parkville Australia
- Royal Children's Hospital; Parkville Australia
- University of Queensland; St Lucia Australia
- Royal Melbourne Hospital; Parkville Australia
- Australian Pregnancy Register for Women with Epilepsy and Allied Conditions; Kew Australia
Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.
|Journal||Annals of Clinical and Translational Neurology|
|Early online date||3 Jul 2014|
|Publication status||Published - 25 Jul 2014|