Altered cortical thickness following prenatal sodium valproate exposure

Research output: Contribution to journalArticle

Authors

  • Jian Chen
  • Sarah Barton
  • Caroline Nadebaum
  • Vicki A. Anderson
  • Cathy Catroppa
  • David C. Reutens
  • Terence J. O'brien
  • Frank Vajda

Colleges, School and Institutes

External organisations

  • The University of Melbourne, Parkville VIC 3010, Australia
  • Southern Clinical School, Monash University, Clayton, Australia.
  • Murdoch Childrens Research Institute; Parkville Australia
  • Royal Children's Hospital; Parkville Australia
  • University of Queensland; St Lucia Australia
  • Royal Melbourne Hospital; Parkville Australia
  • Australian Pregnancy Register for Women with Epilepsy and Allied Conditions; Kew Australia

Abstract

Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.

Details

Original languageEnglish
Pages (from-to)497-501
JournalAnnals of Clinical and Translational Neurology
Volume1
Issue number7
Early online date3 Jul 2014
Publication statusPublished - 25 Jul 2014