Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

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Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma. / Ludwig, C; Williams, D S; Bartlett, D B; Essex, S J; McNee, G; Allwood, J W; Jewell, E; Barkhuisen, A; Parry, H; Anandram, S; Nicolson, P; Gardener, C; Seymour, F; Basu, S; Dunn, W B; Moss, P A H; Pratt, G; Tennant, D A.

In: Blood Cancer Journal, Vol. 5, e359, 16.10.2015.

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@article{464df6d55f294f199610c8a9f7f36f74,
title = "Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma",
abstract = "Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS). The biological mechanisms for disease progression are not well understood. As acquisition of malignant phenotypes by a tumour is often associated with metabolic transformation, the cancer metabolome may act as a dynamic read-out of its phenotype. The aim of this investigation was therefore to characterise the metabolic profile within the bone marrow of healthy donors and patients with MGUS or MM, and to determine if any observed differences between these disorders could be observed within peripheral plasma. ",
author = "C Ludwig and Williams, {D S} and Bartlett, {D B} and Essex, {S J} and G McNee and Allwood, {J W} and E Jewell and A Barkhuisen and H Parry and S Anandram and P Nicolson and C Gardener and F Seymour and S Basu and Dunn, {W B} and Moss, {P A H} and G Pratt and Tennant, {D A}",
year = "2015",
month = oct,
day = "16",
doi = "10.1038/bcj.2015.85",
language = "English",
volume = "5",
journal = "Blood Cancer Journal",
issn = "2044-5385",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

AU - Ludwig, C

AU - Williams, D S

AU - Bartlett, D B

AU - Essex, S J

AU - McNee, G

AU - Allwood, J W

AU - Jewell, E

AU - Barkhuisen, A

AU - Parry, H

AU - Anandram, S

AU - Nicolson, P

AU - Gardener, C

AU - Seymour, F

AU - Basu, S

AU - Dunn, W B

AU - Moss, P A H

AU - Pratt, G

AU - Tennant, D A

PY - 2015/10/16

Y1 - 2015/10/16

N2 - Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS). The biological mechanisms for disease progression are not well understood. As acquisition of malignant phenotypes by a tumour is often associated with metabolic transformation, the cancer metabolome may act as a dynamic read-out of its phenotype. The aim of this investigation was therefore to characterise the metabolic profile within the bone marrow of healthy donors and patients with MGUS or MM, and to determine if any observed differences between these disorders could be observed within peripheral plasma.

AB - Multiple myeloma (MM) is a malignant disorder of plasma cells arising from a clinically benign state known as monoclonal gammopathy of undetermined significance (MGUS). The biological mechanisms for disease progression are not well understood. As acquisition of malignant phenotypes by a tumour is often associated with metabolic transformation, the cancer metabolome may act as a dynamic read-out of its phenotype. The aim of this investigation was therefore to characterise the metabolic profile within the bone marrow of healthy donors and patients with MGUS or MM, and to determine if any observed differences between these disorders could be observed within peripheral plasma.

U2 - 10.1038/bcj.2015.85

DO - 10.1038/bcj.2015.85

M3 - Letter

C2 - 26473531

VL - 5

JO - Blood Cancer Journal

JF - Blood Cancer Journal

SN - 2044-5385

M1 - e359

ER -