Alpha-synuclein repeat variants and survival in Parkinson's disease

Sun Ju Chung; Joanna M Biernacka; Sebastian M Armasu; Kari Anderson; Roberta Frigerio; Jan O Aasly; Grazia Annesi; Anna Rita Bentivoglio; Laura Brighina; Marie-Christine Chartier-Harlin; Stefano Goldwurm; Georgios Hadjigeorgiou; Barbara Jasinska-Myga; Beom Seok Jeon; Yun Joong Kim; Rejko Krüger; Suzanne Lesage; Katerina Markopoulou; George Mellick; Karen E Morrison; Andreas Puschmann; Eng-King Tan; David Crosiers; Jessie Theuns; Christine Van Broeckhoven; Karin Wirdefeldt; Zbigniew K Wszolek; Alexis Elbaz; Demetrius M Maraganore; Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium; Karen Morrison

doi:10.1002/mds.25841

Alpha-synuclein repeat variants and survival in Parkinson's disease

Sun Ju Chung, Joanna M Biernacka, Sebastian M Armasu, Kari Anderson, Roberta Frigerio, Jan O Aasly, Grazia Annesi, Anna Rita Bentivoglio, Laura Brighina, Marie-Christine Chartier-Harlin, Stefano Goldwurm, Georgios Hadjigeorgiou, Barbara Jasinska-Myga, Beom Seok Jeon, Yun Joong Kim, Rejko Krüger, Suzanne Lesage, Katerina Markopoulou, George Mellick, Karen E MorrisonAndreas Puschmann, Eng-King Tan, David Crosiers, Jessie Theuns, Christine Van Broeckhoven, Karin Wirdefeldt, Zbigniew K Wszolek, Alexis Elbaz, Demetrius M Maraganore, Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium, Karen Morrison

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

OBJECTIVES: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).

METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.

RESULTS: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01).

CONCLUSIONS: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.

Original language	English
Pages (from-to)	1053-7
Number of pages	5
Journal	Movement Disorders
Volume	29
Issue number	8
DOIs	https://doi.org/10.1002/mds.25841
Publication status	Published - Jul 2014

Bibliographical note

Keywords

Adult
Age of Onset
Aged
Aged, 80 and over
Dinucleotide Repeats
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
International Cooperation
Male
Middle Aged
Parkinson Disease
Survival
alpha-Synuclein

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Chung, S. J., Biernacka, J. M., Armasu, S. M., Anderson, K., Frigerio, R., Aasly, J. O., Annesi, G., Bentivoglio, A. R., Brighina, L., Chartier-Harlin, M.-C., Goldwurm, S., Hadjigeorgiou, G., Jasinska-Myga, B., Jeon, B. S., Kim, Y. J., Krüger, R., Lesage, S., Markopoulou, K., Mellick, G., ... Morrison, K. (2014). Alpha-synuclein repeat variants and survival in Parkinson's disease. Movement Disorders, 29(8), 1053-7. https://doi.org/10.1002/mds.25841

@article{bb4265ec1f2a4ec48a1b7f369f50f423,

title = "Alpha-synuclein repeat variants and survival in Parkinson's disease",

abstract = "OBJECTIVES: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.RESULTS: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01).CONCLUSIONS: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.",

keywords = "Adult, Age of Onset, Aged, Aged, 80 and over, Dinucleotide Repeats, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, International Cooperation, Male, Middle Aged, Parkinson Disease, Survival, alpha-Synuclein",

author = "Chung, {Sun Ju} and Biernacka, {Joanna M} and Armasu, {Sebastian M} and Kari Anderson and Roberta Frigerio and Aasly, {Jan O} and Grazia Annesi and Bentivoglio, {Anna Rita} and Laura Brighina and Marie-Christine Chartier-Harlin and Stefano Goldwurm and Georgios Hadjigeorgiou and Barbara Jasinska-Myga and Jeon, {Beom Seok} and Kim, {Yun Joong} and Rejko Kr{\"u}ger and Suzanne Lesage and Katerina Markopoulou and George Mellick and Morrison, {Karen E} and Andreas Puschmann and Eng-King Tan and David Crosiers and Jessie Theuns and {Van Broeckhoven}, Christine and Karin Wirdefeldt and Wszolek, {Zbigniew K} and Alexis Elbaz and Maraganore, {Demetrius M} and {Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium} and Karen Morrison",

note = "{\textcopyright} 2014 International Parkinson and Movement Disorder Society.",

year = "2014",

month = jul,

doi = "10.1002/mds.25841",

language = "English",

volume = "29",

pages = "1053--7",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "Wiley",

number = "8",

}

Chung, SJ, Biernacka, JM, Armasu, SM, Anderson, K, Frigerio, R, Aasly, JO, Annesi, G, Bentivoglio, AR, Brighina, L, Chartier-Harlin, M-C, Goldwurm, S, Hadjigeorgiou, G, Jasinska-Myga, B, Jeon, BS, Kim, YJ, Krüger, R, Lesage, S, Markopoulou, K, Mellick, G, Morrison, KE, Puschmann, A, Tan, E-K, Crosiers, D, Theuns, J, Van Broeckhoven, C, Wirdefeldt, K, Wszolek, ZK, Elbaz, A, Maraganore, DM, Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium & Morrison, K 2014, 'Alpha-synuclein repeat variants and survival in Parkinson's disease', Movement Disorders, vol. 29, no. 8, pp. 1053-7. https://doi.org/10.1002/mds.25841

TY - JOUR

T1 - Alpha-synuclein repeat variants and survival in Parkinson's disease

AU - Chung, Sun Ju

AU - Biernacka, Joanna M

AU - Armasu, Sebastian M

AU - Anderson, Kari

AU - Frigerio, Roberta

AU - Aasly, Jan O

AU - Annesi, Grazia

AU - Bentivoglio, Anna Rita

AU - Brighina, Laura

AU - Chartier-Harlin, Marie-Christine

AU - Goldwurm, Stefano

AU - Hadjigeorgiou, Georgios

AU - Jasinska-Myga, Barbara

AU - Jeon, Beom Seok

AU - Kim, Yun Joong

AU - Krüger, Rejko

AU - Lesage, Suzanne

AU - Markopoulou, Katerina

AU - Mellick, George

AU - Morrison, Karen E

AU - Puschmann, Andreas

AU - Tan, Eng-King

AU - Crosiers, David

AU - Theuns, Jessie

AU - Van Broeckhoven, Christine

AU - Wirdefeldt, Karin

AU - Wszolek, Zbigniew K

AU - Elbaz, Alexis

AU - Maraganore, Demetrius M

AU - Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium

AU - Morrison, Karen

PY - 2014/7

Y1 - 2014/7

N2 - OBJECTIVES: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.RESULTS: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01).CONCLUSIONS: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.

AB - OBJECTIVES: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.RESULTS: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01).CONCLUSIONS: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.

KW - Adult

KW - Age of Onset

KW - Aged

KW - Aged, 80 and over

KW - Dinucleotide Repeats

KW - Female

KW - Gene Frequency

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - International Cooperation

KW - Male

KW - Middle Aged

KW - Parkinson Disease

KW - Survival

KW - alpha-Synuclein

U2 - 10.1002/mds.25841

DO - 10.1002/mds.25841

M3 - Article

C2 - 24578302

SN - 0885-3185

VL - 29

SP - 1053

EP - 1057

JO - Movement Disorders

JF - Movement Disorders

IS - 8

ER -

Alpha-synuclein repeat variants and survival in Parkinson's disease

Abstract

Bibliographical note

Keywords

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