Alpha cell function in type 1 diabetes
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
Our understanding of the pathogenesis of type 1 diabetes mellitus has traditionally revolved around the insulin deficiency that follows pancreatic beta cell loss. However, there is an increasing appreciation of defects in other gluco-regulatory cells in type 1 diabetes mellitus. Oversecretion of glucagon from pancreatic alpha cells is characteristic of type 1 diabetes mellitus, and modulating these glucagon levels reduces hyperglycaemia. This article reviews alpha cell function in type 1 diabetes mellitus. We examine how its function is controlled and compromised, and review studies that target alpha cell function. Finally, we explore potential approaches to modulating alpha cell function in type 1 diabetes mellitus.
|Number of pages||7|
|Journal||The British Journal of Diabetes & Vascular Disease|
|Publication status||Published - Apr 2014|
- alpha cell, glucagon, siabetes, type 1, Islets of Langerhans, DPP-4, GLP-1, insulin