Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia

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Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia. / Tauro, S.; Craddock, C.; Peggs, K.; Begum, G.; Mahendra, P.; Cook, G.; Marsh, J.; Milligan, D.; Goldstone, Anthony; Hunter, A.; Khwaja, A.; Chopra, R.; Littlewood, Tim; Peniket, A.; Parker, Anne; Jackson, Graham; Hale, Geoff; Cook, M.; Russell, Nigel; Mackinnon, S.

In: Journal of Clinical Oncology, Vol. 23, No. 36, 28.11.2005, p. 9387-9393.

Research output: Contribution to journalArticlepeer-review

Harvard

Tauro, S, Craddock, C, Peggs, K, Begum, G, Mahendra, P, Cook, G, Marsh, J, Milligan, D, Goldstone, A, Hunter, A, Khwaja, A, Chopra, R, Littlewood, T, Peniket, A, Parker, A, Jackson, G, Hale, G, Cook, M, Russell, N & Mackinnon, S 2005, 'Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia', Journal of Clinical Oncology, vol. 23, no. 36, pp. 9387-9393. https://doi.org/10.1200/JCO.2005.02.0057

APA

Tauro, S., Craddock, C., Peggs, K., Begum, G., Mahendra, P., Cook, G., Marsh, J., Milligan, D., Goldstone, A., Hunter, A., Khwaja, A., Chopra, R., Littlewood, T., Peniket, A., Parker, A., Jackson, G., Hale, G., Cook, M., Russell, N., & Mackinnon, S. (2005). Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia. Journal of Clinical Oncology, 23(36), 9387-9393. https://doi.org/10.1200/JCO.2005.02.0057

Vancouver

Author

Tauro, S. ; Craddock, C. ; Peggs, K. ; Begum, G. ; Mahendra, P. ; Cook, G. ; Marsh, J. ; Milligan, D. ; Goldstone, Anthony ; Hunter, A. ; Khwaja, A. ; Chopra, R. ; Littlewood, Tim ; Peniket, A. ; Parker, Anne ; Jackson, Graham ; Hale, Geoff ; Cook, M. ; Russell, Nigel ; Mackinnon, S. / Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 36. pp. 9387-9393.

Bibtex

@article{517666fda88f4e0289f5a27a6d137c4b,
title = "Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia",
abstract = "Purpose The toxicity of allogeneic stem-cell transplantation can be substantially reduced using a reduced-intensity conditioning (RIC) regimen. This has increased the proportion of patients with myeloid malignancies eligible for allogeneic transplantation. However, the capacity of RIC allografts to produce durable remissions in patients with acute myeloid leukemia (AML) and myelodysplasia (MDS) has not yet been defined, and consequently, the role of RIC allografts in the management of these diseases remains conjectural. Patients and Methods Seventy-six patients with high-risk AML or MDS received an allograft using a fludarabine/ melphalan RIC regimen incorporating alemtuzumab. The median age of the cohort was 52 years (range, 18 to 71 years). Results The 100-day transplantation-related mortality rate was 9%, and no patient developed greater than grade 2 graft-versus-host disease. With a median follow-up of 36 months (range, 13 to 70 months), 27 patients were alive and in remission, with 3-year actuarial overall survival (CIS) and disease-free survival (DFS) rates of 41 % and 37%, respectively. The 3-year CIS and DIFS rates of patients with AML in complete remission at the time of transplantation were 48% and 42%, respectively. Disease relapse was the most common cause of treatment failure and occurred at a median time of 6 months after transplantation. All but one patient destined to relapse did so within 24 months of transplantation. Conclusion The extended follow-up in this series identifies a high risk of early disease relapse but provides evidence that RIC allografts can produce sustained DFS in a significant number of patients with AML who would be ineligible for allogeneic transplantation with myeloablative conditioning.",
keywords = "bone-marrow-transplantation southwest-oncology-group 1st complete remission versus-host-disease in-vivo aml immunotherapy malignancies fludarabine busulfan",
author = "S. Tauro and C. Craddock and K. Peggs and G. Begum and P. Mahendra and G. Cook and J. Marsh and D. Milligan and Anthony Goldstone and A. Hunter and A. Khwaja and R. Chopra and Tim Littlewood and A. Peniket and Anne Parker and Graham Jackson and Geoff Hale and M. Cook and Nigel Russell and S. Mackinnon",
year = "2005",
month = nov,
day = "28",
doi = "10.1200/JCO.2005.02.0057",
language = "English",
volume = "23",
pages = "9387--9393",
journal = "Journal of Clinical Oncology ",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "36",

}

RIS

TY - JOUR

T1 - Allogeneic stem-cell transplantation using a reduced-intensity conditioning regimen has the capacity to produce durable remissions and long-term disease-free survival in patients with high-risk acute myeloid leukemia and myelodysplasia

AU - Tauro, S.

AU - Craddock, C.

AU - Peggs, K.

AU - Begum, G.

AU - Mahendra, P.

AU - Cook, G.

AU - Marsh, J.

AU - Milligan, D.

AU - Goldstone, Anthony

AU - Hunter, A.

AU - Khwaja, A.

AU - Chopra, R.

AU - Littlewood, Tim

AU - Peniket, A.

AU - Parker, Anne

AU - Jackson, Graham

AU - Hale, Geoff

AU - Cook, M.

AU - Russell, Nigel

AU - Mackinnon, S.

PY - 2005/11/28

Y1 - 2005/11/28

N2 - Purpose The toxicity of allogeneic stem-cell transplantation can be substantially reduced using a reduced-intensity conditioning (RIC) regimen. This has increased the proportion of patients with myeloid malignancies eligible for allogeneic transplantation. However, the capacity of RIC allografts to produce durable remissions in patients with acute myeloid leukemia (AML) and myelodysplasia (MDS) has not yet been defined, and consequently, the role of RIC allografts in the management of these diseases remains conjectural. Patients and Methods Seventy-six patients with high-risk AML or MDS received an allograft using a fludarabine/ melphalan RIC regimen incorporating alemtuzumab. The median age of the cohort was 52 years (range, 18 to 71 years). Results The 100-day transplantation-related mortality rate was 9%, and no patient developed greater than grade 2 graft-versus-host disease. With a median follow-up of 36 months (range, 13 to 70 months), 27 patients were alive and in remission, with 3-year actuarial overall survival (CIS) and disease-free survival (DFS) rates of 41 % and 37%, respectively. The 3-year CIS and DIFS rates of patients with AML in complete remission at the time of transplantation were 48% and 42%, respectively. Disease relapse was the most common cause of treatment failure and occurred at a median time of 6 months after transplantation. All but one patient destined to relapse did so within 24 months of transplantation. Conclusion The extended follow-up in this series identifies a high risk of early disease relapse but provides evidence that RIC allografts can produce sustained DFS in a significant number of patients with AML who would be ineligible for allogeneic transplantation with myeloablative conditioning.

AB - Purpose The toxicity of allogeneic stem-cell transplantation can be substantially reduced using a reduced-intensity conditioning (RIC) regimen. This has increased the proportion of patients with myeloid malignancies eligible for allogeneic transplantation. However, the capacity of RIC allografts to produce durable remissions in patients with acute myeloid leukemia (AML) and myelodysplasia (MDS) has not yet been defined, and consequently, the role of RIC allografts in the management of these diseases remains conjectural. Patients and Methods Seventy-six patients with high-risk AML or MDS received an allograft using a fludarabine/ melphalan RIC regimen incorporating alemtuzumab. The median age of the cohort was 52 years (range, 18 to 71 years). Results The 100-day transplantation-related mortality rate was 9%, and no patient developed greater than grade 2 graft-versus-host disease. With a median follow-up of 36 months (range, 13 to 70 months), 27 patients were alive and in remission, with 3-year actuarial overall survival (CIS) and disease-free survival (DFS) rates of 41 % and 37%, respectively. The 3-year CIS and DIFS rates of patients with AML in complete remission at the time of transplantation were 48% and 42%, respectively. Disease relapse was the most common cause of treatment failure and occurred at a median time of 6 months after transplantation. All but one patient destined to relapse did so within 24 months of transplantation. Conclusion The extended follow-up in this series identifies a high risk of early disease relapse but provides evidence that RIC allografts can produce sustained DFS in a significant number of patients with AML who would be ineligible for allogeneic transplantation with myeloablative conditioning.

KW - bone-marrow-transplantation southwest-oncology-group 1st complete remission versus-host-disease in-vivo aml immunotherapy malignancies fludarabine busulfan

UR - http://www.scopus.com/inward/record.url?scp=33644820764&partnerID=8YFLogxK

U2 - 10.1200/JCO.2005.02.0057

DO - 10.1200/JCO.2005.02.0057

M3 - Article

C2 - 16314618

VL - 23

SP - 9387

EP - 9393

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 36

ER -