Allogeneic stem cell transplant in adult patients with acute myelogenous leukemia: a systematic analysis of international guidelines and recommendations

Research output: Contribution to journalArticle

Authors

  • K Huebel
  • O Weingart
  • F Naumann
  • J Bohlius
  • MM Fresen
  • A Engert

Abstract

In patients with acute myelogenous leukemia, published guidelines and treatment recommendations are usually the basis for starting the work-up process for allogeneic transplant. However, only consistent recommendations would allow a standardized clinical practice. We conducted a comprehensive systematic literature search to identify and evaluate the best available evidence from controlled clinical trials. In addition, recommendations given by leading organizations in the USA and Europe were analyzed. The following aspects were selected for systematic comparison: factors for risk assessment and categorization, role of type of donor, significance of allogeneic transplant in first or second complete remission and in relapse/progressive disease; and role of reduced intensity conditioning regimens. In conclusion, the recommendations for the use of allogeneic transplant given by the literature and by published guidelines are inconsistent and will need clarification.

Details

Original languageEnglish
Pages (from-to)444-457
Number of pages14
JournalLeukemia and Lymphoma
Volume52
Issue number3
Early online date16 Feb 2011
Publication statusPublished - Mar 2011

Keywords

  • Adult, Controlled Clinical Trials as Topic, Donor Selection, Health Planning Guidelines, Humans, Internationality, Leukemia, Myeloid, Acute, Patient Selection, Practice Guidelines as Topic, Stem Cell Transplantation, Transplantation, Homologous