Alcohol sensitivity, alcohol use and high-sensitivity C-reactive protein in older Chinese men: The Guangzhou Biobank Cohort Study

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Alcohol sensitivity, alcohol use and high-sensitivity C-reactive protein in older Chinese men: The Guangzhou Biobank Cohort Study. / Xu, Shao Jun; Jiang, Chao Qiang; Zhang, Wei Sen; Cheng, Kar Keung; Schooling, Catherine Mary; Xu, Lin; Liu, Bin; Jin, Ya Li; Hubert Lam, Kin Bong; Lam, Tai Hing.

In: Alcohol, Vol. 57, 01.12.2016, p. 41-48.

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Xu, Shao Jun ; Jiang, Chao Qiang ; Zhang, Wei Sen ; Cheng, Kar Keung ; Schooling, Catherine Mary ; Xu, Lin ; Liu, Bin ; Jin, Ya Li ; Hubert Lam, Kin Bong ; Lam, Tai Hing. / Alcohol sensitivity, alcohol use and high-sensitivity C-reactive protein in older Chinese men: The Guangzhou Biobank Cohort Study. In: Alcohol. 2016 ; Vol. 57. pp. 41-48.

Bibtex

@article{711bbfcec738487cba08f0fcc07878ed,
title = "Alcohol sensitivity, alcohol use and high-sensitivity C-reactive protein in older Chinese men: The Guangzhou Biobank Cohort Study",
abstract = "Compared to other ethnic groups Asians are more likely to be sensitive to alcohol, due to polymorphisms of alcohol-metabolizing enzymes. Although previous studies have found positive association between regular alcohol use and high-sensitivity C-reactive protein (HsCRP), whether this association is modified by alcohol sensitivity has not been clarified. We therefore sought to examined this potential effect modification in a cross-sectional community sample with high prevalence of alcohol sensitivity, using data from 2903 men aged ≥50years recruited during phase 1 of the Guangzhou Biobank Cohort Study. Information on alcohol consumption and sensitivity (facial flushing, palpitation or dizziness after drinking) was obtained by questionnaire and HsCRP was measured by an immunoturbidometric assay. Elevated HsCRP was defined as HsCRP level equal to or higher than 2.81 mg/L(median). Excessive alcohol use was defined as use of ≥210 g ethanol per week. After adjustment for age, educational level, occupation, smoking status, physical activity and history of cardiovascular disease, alcohol use was associated with HsCRP in a dose-response pattern. The risks of elevated HsCRP were higher in those who drank daily (odds ratio (OR) = 1.38 (1.10, 1.72)) or drank excessively (1.57 (1.22, 2.02)), and were even higher in alcohol users with alcohol sensitivity (1.82 (1.24, 2.65) for daily users and 2.34 (1.48, 3.71) for excessive users). Results of this study have showed an important role of alcohol sensitivity in modifying the association between alcohol use and HsCRP level. Reduction of alcohol use should be an important public heath target, particularly among populations with high prevalence of alcohol sensitivity.",
keywords = "Alcohol sensitivity, Alcohol use, High-sensitivity C reactive protein, China",
author = "Xu, {Shao Jun} and Jiang, {Chao Qiang} and Zhang, {Wei Sen} and Cheng, {Kar Keung} and Schooling, {Catherine Mary} and Lin Xu and Bin Liu and Jin, {Ya Li} and {Hubert Lam}, {Kin Bong} and Lam, {Tai Hing}",
year = "2016",
month = dec,
day = "1",
doi = "10.1016/j.alcohol.2016.10.011",
language = "English",
volume = "57",
pages = "41--48",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Alcohol sensitivity, alcohol use and high-sensitivity C-reactive protein in older Chinese men: The Guangzhou Biobank Cohort Study

AU - Xu, Shao Jun

AU - Jiang, Chao Qiang

AU - Zhang, Wei Sen

AU - Cheng, Kar Keung

AU - Schooling, Catherine Mary

AU - Xu, Lin

AU - Liu, Bin

AU - Jin, Ya Li

AU - Hubert Lam, Kin Bong

AU - Lam, Tai Hing

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Compared to other ethnic groups Asians are more likely to be sensitive to alcohol, due to polymorphisms of alcohol-metabolizing enzymes. Although previous studies have found positive association between regular alcohol use and high-sensitivity C-reactive protein (HsCRP), whether this association is modified by alcohol sensitivity has not been clarified. We therefore sought to examined this potential effect modification in a cross-sectional community sample with high prevalence of alcohol sensitivity, using data from 2903 men aged ≥50years recruited during phase 1 of the Guangzhou Biobank Cohort Study. Information on alcohol consumption and sensitivity (facial flushing, palpitation or dizziness after drinking) was obtained by questionnaire and HsCRP was measured by an immunoturbidometric assay. Elevated HsCRP was defined as HsCRP level equal to or higher than 2.81 mg/L(median). Excessive alcohol use was defined as use of ≥210 g ethanol per week. After adjustment for age, educational level, occupation, smoking status, physical activity and history of cardiovascular disease, alcohol use was associated with HsCRP in a dose-response pattern. The risks of elevated HsCRP were higher in those who drank daily (odds ratio (OR) = 1.38 (1.10, 1.72)) or drank excessively (1.57 (1.22, 2.02)), and were even higher in alcohol users with alcohol sensitivity (1.82 (1.24, 2.65) for daily users and 2.34 (1.48, 3.71) for excessive users). Results of this study have showed an important role of alcohol sensitivity in modifying the association between alcohol use and HsCRP level. Reduction of alcohol use should be an important public heath target, particularly among populations with high prevalence of alcohol sensitivity.

AB - Compared to other ethnic groups Asians are more likely to be sensitive to alcohol, due to polymorphisms of alcohol-metabolizing enzymes. Although previous studies have found positive association between regular alcohol use and high-sensitivity C-reactive protein (HsCRP), whether this association is modified by alcohol sensitivity has not been clarified. We therefore sought to examined this potential effect modification in a cross-sectional community sample with high prevalence of alcohol sensitivity, using data from 2903 men aged ≥50years recruited during phase 1 of the Guangzhou Biobank Cohort Study. Information on alcohol consumption and sensitivity (facial flushing, palpitation or dizziness after drinking) was obtained by questionnaire and HsCRP was measured by an immunoturbidometric assay. Elevated HsCRP was defined as HsCRP level equal to or higher than 2.81 mg/L(median). Excessive alcohol use was defined as use of ≥210 g ethanol per week. After adjustment for age, educational level, occupation, smoking status, physical activity and history of cardiovascular disease, alcohol use was associated with HsCRP in a dose-response pattern. The risks of elevated HsCRP were higher in those who drank daily (odds ratio (OR) = 1.38 (1.10, 1.72)) or drank excessively (1.57 (1.22, 2.02)), and were even higher in alcohol users with alcohol sensitivity (1.82 (1.24, 2.65) for daily users and 2.34 (1.48, 3.71) for excessive users). Results of this study have showed an important role of alcohol sensitivity in modifying the association between alcohol use and HsCRP level. Reduction of alcohol use should be an important public heath target, particularly among populations with high prevalence of alcohol sensitivity.

KW - Alcohol sensitivity

KW - Alcohol use

KW - High-sensitivity C reactive protein

KW - China

U2 - 10.1016/j.alcohol.2016.10.011

DO - 10.1016/j.alcohol.2016.10.011

M3 - Article

VL - 57

SP - 41

EP - 48

JO - Alcohol

JF - Alcohol

SN - 0741-8329

ER -