Alcohol intake and prognosis of atrial fibrillation

Research output: Contribution to journalArticle

Standard

Alcohol intake and prognosis of atrial fibrillation. / Overvad, Thure Filskov; Rasmussen, Lars Hvilsted; Skjøth, Flemming; Overvad, Kim; Albertsen, Ida Ehlers; Lane, Deirdre; Lip, Gregory Y H; Larsen, Torben Bjerregaard.

In: Heart, Vol. 99, No. 15, 08.2013, p. 1093-9.

Research output: Contribution to journalArticle

Harvard

Overvad, TF, Rasmussen, LH, Skjøth, F, Overvad, K, Albertsen, IE, Lane, D, Lip, GYH & Larsen, TB 2013, 'Alcohol intake and prognosis of atrial fibrillation', Heart, vol. 99, no. 15, pp. 1093-9. https://doi.org/10.1136/heartjnl-2013-304036

APA

Overvad, T. F., Rasmussen, L. H., Skjøth, F., Overvad, K., Albertsen, I. E., Lane, D., Lip, G. Y. H., & Larsen, T. B. (2013). Alcohol intake and prognosis of atrial fibrillation. Heart, 99(15), 1093-9. https://doi.org/10.1136/heartjnl-2013-304036

Vancouver

Overvad TF, Rasmussen LH, Skjøth F, Overvad K, Albertsen IE, Lane D et al. Alcohol intake and prognosis of atrial fibrillation. Heart. 2013 Aug;99(15):1093-9. https://doi.org/10.1136/heartjnl-2013-304036

Author

Overvad, Thure Filskov ; Rasmussen, Lars Hvilsted ; Skjøth, Flemming ; Overvad, Kim ; Albertsen, Ida Ehlers ; Lane, Deirdre ; Lip, Gregory Y H ; Larsen, Torben Bjerregaard. / Alcohol intake and prognosis of atrial fibrillation. In: Heart. 2013 ; Vol. 99, No. 15. pp. 1093-9.

Bibtex

@article{12fa8f7063084f77a6a3f82b617bdd3e,
title = "Alcohol intake and prognosis of atrial fibrillation",
abstract = "OBJECTIVE: To assess alcohol intake as a risk factor for adverse events among patients with incident atrial fibrillation (AF).DESIGN: Prospective cohort study.SETTING: Population based cohort study and nationwide Danish registries.PATIENTS: The Danish Diet, Cancer and Health study included 57 053 participants (27 178 men and 29 875 women) aged between 50 and 64 years. The study population for this study included the 3107 participants (1999 men, 1108 women) who developed incident AF after inclusion.MAIN OUTCOME MEASURES: A composite of thromboembolism or death.RESULTS: During a median follow-up of 4.9 years 608 deaths and 211 thromboembolic events occurred. Of those who developed AF, 690 (35%) men and 233 (21%) women had a high intake of alcohol (>20 drinks/week for men and >13 drinks/week for women). After adjustment for use of oral anticoagulation and components of the CHA2DS2-VASc score, men with an intake of >27 drinks/week had a higher risk for thromboembolism or death (hazard ratio (HR) 1.33, 95% CI 1.08 to 1.63) than men with an intake of <14 drinks/week. Women with an intake of >20 drinks/week also had a higher risk (HR 1.23, 95% CI 0.78 to 1.96) than women in the low intake category. The higher risk among men was primarily driven by mortality (HR 1.51, 95% CI 1.20 to 1.89), whereas the risk found among women was driven by thromboembolism (HR 1.71, 95% CI 0.81 to 3.60).CONCLUSIONS: High alcohol intake predicts thromboembolism or death, even after adjustment for established clinical risk factors, and may help identify high risk AF patients who could be targeted for stroke and cardiovascular prevention strategies.",
keywords = "Age Factors, Aged, Alcohol Drinking, Anticoagulants, Atrial Fibrillation, Cohort Studies, Comorbidity, Denmark, Female, Humans, Male, Medical Records, Problem-Oriented, Middle Aged, Outcome Assessment (Health Care), Risk Assessment, Risk Factors, Sex Factors, Thromboembolism",
author = "Overvad, {Thure Filskov} and Rasmussen, {Lars Hvilsted} and Flemming Skj{\o}th and Kim Overvad and Albertsen, {Ida Ehlers} and Deirdre Lane and Lip, {Gregory Y H} and Larsen, {Torben Bjerregaard}",
year = "2013",
month = aug,
doi = "10.1136/heartjnl-2013-304036",
language = "English",
volume = "99",
pages = "1093--9",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
number = "15",

}

RIS

TY - JOUR

T1 - Alcohol intake and prognosis of atrial fibrillation

AU - Overvad, Thure Filskov

AU - Rasmussen, Lars Hvilsted

AU - Skjøth, Flemming

AU - Overvad, Kim

AU - Albertsen, Ida Ehlers

AU - Lane, Deirdre

AU - Lip, Gregory Y H

AU - Larsen, Torben Bjerregaard

PY - 2013/8

Y1 - 2013/8

N2 - OBJECTIVE: To assess alcohol intake as a risk factor for adverse events among patients with incident atrial fibrillation (AF).DESIGN: Prospective cohort study.SETTING: Population based cohort study and nationwide Danish registries.PATIENTS: The Danish Diet, Cancer and Health study included 57 053 participants (27 178 men and 29 875 women) aged between 50 and 64 years. The study population for this study included the 3107 participants (1999 men, 1108 women) who developed incident AF after inclusion.MAIN OUTCOME MEASURES: A composite of thromboembolism or death.RESULTS: During a median follow-up of 4.9 years 608 deaths and 211 thromboembolic events occurred. Of those who developed AF, 690 (35%) men and 233 (21%) women had a high intake of alcohol (>20 drinks/week for men and >13 drinks/week for women). After adjustment for use of oral anticoagulation and components of the CHA2DS2-VASc score, men with an intake of >27 drinks/week had a higher risk for thromboembolism or death (hazard ratio (HR) 1.33, 95% CI 1.08 to 1.63) than men with an intake of <14 drinks/week. Women with an intake of >20 drinks/week also had a higher risk (HR 1.23, 95% CI 0.78 to 1.96) than women in the low intake category. The higher risk among men was primarily driven by mortality (HR 1.51, 95% CI 1.20 to 1.89), whereas the risk found among women was driven by thromboembolism (HR 1.71, 95% CI 0.81 to 3.60).CONCLUSIONS: High alcohol intake predicts thromboembolism or death, even after adjustment for established clinical risk factors, and may help identify high risk AF patients who could be targeted for stroke and cardiovascular prevention strategies.

AB - OBJECTIVE: To assess alcohol intake as a risk factor for adverse events among patients with incident atrial fibrillation (AF).DESIGN: Prospective cohort study.SETTING: Population based cohort study and nationwide Danish registries.PATIENTS: The Danish Diet, Cancer and Health study included 57 053 participants (27 178 men and 29 875 women) aged between 50 and 64 years. The study population for this study included the 3107 participants (1999 men, 1108 women) who developed incident AF after inclusion.MAIN OUTCOME MEASURES: A composite of thromboembolism or death.RESULTS: During a median follow-up of 4.9 years 608 deaths and 211 thromboembolic events occurred. Of those who developed AF, 690 (35%) men and 233 (21%) women had a high intake of alcohol (>20 drinks/week for men and >13 drinks/week for women). After adjustment for use of oral anticoagulation and components of the CHA2DS2-VASc score, men with an intake of >27 drinks/week had a higher risk for thromboembolism or death (hazard ratio (HR) 1.33, 95% CI 1.08 to 1.63) than men with an intake of <14 drinks/week. Women with an intake of >20 drinks/week also had a higher risk (HR 1.23, 95% CI 0.78 to 1.96) than women in the low intake category. The higher risk among men was primarily driven by mortality (HR 1.51, 95% CI 1.20 to 1.89), whereas the risk found among women was driven by thromboembolism (HR 1.71, 95% CI 0.81 to 3.60).CONCLUSIONS: High alcohol intake predicts thromboembolism or death, even after adjustment for established clinical risk factors, and may help identify high risk AF patients who could be targeted for stroke and cardiovascular prevention strategies.

KW - Age Factors

KW - Aged

KW - Alcohol Drinking

KW - Anticoagulants

KW - Atrial Fibrillation

KW - Cohort Studies

KW - Comorbidity

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Medical Records, Problem-Oriented

KW - Middle Aged

KW - Outcome Assessment (Health Care)

KW - Risk Assessment

KW - Risk Factors

KW - Sex Factors

KW - Thromboembolism

U2 - 10.1136/heartjnl-2013-304036

DO - 10.1136/heartjnl-2013-304036

M3 - Article

C2 - 23766449

VL - 99

SP - 1093

EP - 1099

JO - Heart

JF - Heart

SN - 1355-6037

IS - 15

ER -