Alcohol consumption and electrocardiographic left ventricular hypertrophy and mediation by elevated blood pressure in older Chinese men: the Guangzhou Biobank Cohort Study

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Alcohol consumption and electrocardiographic left ventricular hypertrophy and mediation by elevated blood pressure in older Chinese men : the Guangzhou Biobank Cohort Study. / Long, Mei Jing; Jiang, Chao Qiang; Lam, Tai Hing; Lin, Jie Ming; Chan, Yap Hang; Zhang, Wei Sen; Jin, Ya Li; Liu, Bin; Thomas, G Neil; Cheng, Kar Keung.

In: Alcohol, Vol. 47, No. 6, 09.2013, p. 473-80.

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Long, Mei Jing ; Jiang, Chao Qiang ; Lam, Tai Hing ; Lin, Jie Ming ; Chan, Yap Hang ; Zhang, Wei Sen ; Jin, Ya Li ; Liu, Bin ; Thomas, G Neil ; Cheng, Kar Keung. / Alcohol consumption and electrocardiographic left ventricular hypertrophy and mediation by elevated blood pressure in older Chinese men : the Guangzhou Biobank Cohort Study. In: Alcohol. 2013 ; Vol. 47, No. 6. pp. 473-80.

Bibtex

@article{af7aa67c94dc4ec2b4dba6af67bec789,
title = "Alcohol consumption and electrocardiographic left ventricular hypertrophy and mediation by elevated blood pressure in older Chinese men: the Guangzhou Biobank Cohort Study",
abstract = "BACKGROUND: Chinese people have a markedly lower alcohol consumption than people in the West. Whether alcohol consumption at such levels is associated with left ventricular hypertrophy, and the role of blood pressure (BP) in this relationship is unclear. We investigated the association between alcohol consumption and electrocardiographic left ventricular hypertrophy (ECG-LVH) and the mediating role of BP in Chinese men aged ≥50 years.METHODS AND RESULTS: A case-control analysis was conducted on baseline cross-sectional data from the community-based Guangzhou Biobank Cohort Study (2003-2008), using standard 12-lead resting electrocardiograms. By comparing 191 new ECG-LVH cases with 4311 controls, excessive drinking (>210 g/week) showed excess risks for ECG-LVH (odds ratio [OR] = 1.90, 95% confidence interval [CI] = 1.12-3.24), after adjusting for education, income, occupation, physical activity, smoking, body mass index, fasting glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, BP, and antihypertensive medication. Mediation analysis showed a significant mediating effect of BP on the association between excessive drinking and ECG-LVH: systolic (31%) and diastolic (16%). After multivariate adjustment, no significant association was found between occasional drinking (CONCLUSIONS: Alcohol consumption at >210 g/week in Chinese men is an independent risk factor for ECG-LVH. Low power prevented us from examining whether drinking at ",
keywords = "Aged, Aged, 80 and over, Alcohol Drinking, Asian Continental Ancestry Group, Blood Pressure, Case-Control Studies, Cohort Studies, Cross-Sectional Studies, Electrocardiography, Humans, Hypertension, Hypertrophy, Left Ventricular, Male, Middle Aged, Risk Factors",
author = "Long, {Mei Jing} and Jiang, {Chao Qiang} and Lam, {Tai Hing} and Lin, {Jie Ming} and Chan, {Yap Hang} and Zhang, {Wei Sen} and Jin, {Ya Li} and Bin Liu and Thomas, {G Neil} and Cheng, {Kar Keung}",
note = "Copyright {\textcopyright} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
month = sep,
doi = "10.1016/j.alcohol.2013.06.003",
language = "English",
volume = "47",
pages = "473--80",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Alcohol consumption and electrocardiographic left ventricular hypertrophy and mediation by elevated blood pressure in older Chinese men

T2 - the Guangzhou Biobank Cohort Study

AU - Long, Mei Jing

AU - Jiang, Chao Qiang

AU - Lam, Tai Hing

AU - Lin, Jie Ming

AU - Chan, Yap Hang

AU - Zhang, Wei Sen

AU - Jin, Ya Li

AU - Liu, Bin

AU - Thomas, G Neil

AU - Cheng, Kar Keung

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/9

Y1 - 2013/9

N2 - BACKGROUND: Chinese people have a markedly lower alcohol consumption than people in the West. Whether alcohol consumption at such levels is associated with left ventricular hypertrophy, and the role of blood pressure (BP) in this relationship is unclear. We investigated the association between alcohol consumption and electrocardiographic left ventricular hypertrophy (ECG-LVH) and the mediating role of BP in Chinese men aged ≥50 years.METHODS AND RESULTS: A case-control analysis was conducted on baseline cross-sectional data from the community-based Guangzhou Biobank Cohort Study (2003-2008), using standard 12-lead resting electrocardiograms. By comparing 191 new ECG-LVH cases with 4311 controls, excessive drinking (>210 g/week) showed excess risks for ECG-LVH (odds ratio [OR] = 1.90, 95% confidence interval [CI] = 1.12-3.24), after adjusting for education, income, occupation, physical activity, smoking, body mass index, fasting glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, BP, and antihypertensive medication. Mediation analysis showed a significant mediating effect of BP on the association between excessive drinking and ECG-LVH: systolic (31%) and diastolic (16%). After multivariate adjustment, no significant association was found between occasional drinking (CONCLUSIONS: Alcohol consumption at >210 g/week in Chinese men is an independent risk factor for ECG-LVH. Low power prevented us from examining whether drinking at

AB - BACKGROUND: Chinese people have a markedly lower alcohol consumption than people in the West. Whether alcohol consumption at such levels is associated with left ventricular hypertrophy, and the role of blood pressure (BP) in this relationship is unclear. We investigated the association between alcohol consumption and electrocardiographic left ventricular hypertrophy (ECG-LVH) and the mediating role of BP in Chinese men aged ≥50 years.METHODS AND RESULTS: A case-control analysis was conducted on baseline cross-sectional data from the community-based Guangzhou Biobank Cohort Study (2003-2008), using standard 12-lead resting electrocardiograms. By comparing 191 new ECG-LVH cases with 4311 controls, excessive drinking (>210 g/week) showed excess risks for ECG-LVH (odds ratio [OR] = 1.90, 95% confidence interval [CI] = 1.12-3.24), after adjusting for education, income, occupation, physical activity, smoking, body mass index, fasting glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, BP, and antihypertensive medication. Mediation analysis showed a significant mediating effect of BP on the association between excessive drinking and ECG-LVH: systolic (31%) and diastolic (16%). After multivariate adjustment, no significant association was found between occasional drinking (CONCLUSIONS: Alcohol consumption at >210 g/week in Chinese men is an independent risk factor for ECG-LVH. Low power prevented us from examining whether drinking at

KW - Aged

KW - Aged, 80 and over

KW - Alcohol Drinking

KW - Asian Continental Ancestry Group

KW - Blood Pressure

KW - Case-Control Studies

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Electrocardiography

KW - Humans

KW - Hypertension

KW - Hypertrophy, Left Ventricular

KW - Male

KW - Middle Aged

KW - Risk Factors

U2 - 10.1016/j.alcohol.2013.06.003

DO - 10.1016/j.alcohol.2013.06.003

M3 - Article

C2 - 23938170

VL - 47

SP - 473

EP - 480

JO - Alcohol

JF - Alcohol

SN - 0741-8329

IS - 6

ER -