Airway response to respiratory syncytial virus has incidental antibacterial effects

Research output: Contribution to journalArticle

Standard

Airway response to respiratory syncytial virus has incidental antibacterial effects. / Sande, Charles; Njunge, James; Ngoi, Joyce; Mutunga, Martin; Chege, Timothy; Gicheru, Elijah; Gardiner, Elizabeth; Gwela, Agnes; Green, Christopher; Drysdale, Simon; Berkley, James; Nokes, James; Pollard, Andrew.

In: Nature Communications, Vol. 10, 2218, 17.05.2019.

Research output: Contribution to journalArticle

Harvard

Sande, C, Njunge, J, Ngoi, J, Mutunga, M, Chege, T, Gicheru, E, Gardiner, E, Gwela, A, Green, C, Drysdale, S, Berkley, J, Nokes, J & Pollard, A 2019, 'Airway response to respiratory syncytial virus has incidental antibacterial effects', Nature Communications, vol. 10, 2218. https://doi.org/10.1038/s41467-019-10222-z

APA

Sande, C., Njunge, J., Ngoi, J., Mutunga, M., Chege, T., Gicheru, E., Gardiner, E., Gwela, A., Green, C., Drysdale, S., Berkley, J., Nokes, J., & Pollard, A. (2019). Airway response to respiratory syncytial virus has incidental antibacterial effects. Nature Communications, 10, [2218]. https://doi.org/10.1038/s41467-019-10222-z

Vancouver

Author

Sande, Charles ; Njunge, James ; Ngoi, Joyce ; Mutunga, Martin ; Chege, Timothy ; Gicheru, Elijah ; Gardiner, Elizabeth ; Gwela, Agnes ; Green, Christopher ; Drysdale, Simon ; Berkley, James ; Nokes, James ; Pollard, Andrew. / Airway response to respiratory syncytial virus has incidental antibacterial effects. In: Nature Communications. 2019 ; Vol. 10.

Bibtex

@article{bd0e9028c6e5424d896bb7600d610d07,
title = "Airway response to respiratory syncytial virus has incidental antibacterial effects",
abstract = "RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics analysis we simultaneously analysed the microbiota and proteomes of the upper airway and determined direct antibacterial activity in airway secretions of RSV-infected children. Here, we report that the airway abundance of Streptococcus was higher in samples collected at the time of RSV infection compared with samples collected one month later. RSV infection is associated with neutrophil influx into the airway and degranulation and is marked by overexpression of proteins with known antibacterial activity including BPI, EPX, MPO and AZU1. Airway secretions of children infected with RSV, have significantly greater antibacterial activity compared to RSV-negative controls. This RSV-associated, neutrophil-mediated antibacterial response in the airway appears to act as a regulatory mechanism that modulates bacterial growth in the airways of RSV-infected children.",
author = "Charles Sande and James Njunge and Joyce Ngoi and Martin Mutunga and Timothy Chege and Elijah Gicheru and Elizabeth Gardiner and Agnes Gwela and Christopher Green and Simon Drysdale and James Berkley and James Nokes and Andrew Pollard",
year = "2019",
month = may,
day = "17",
doi = "10.1038/s41467-019-10222-z",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Airway response to respiratory syncytial virus has incidental antibacterial effects

AU - Sande, Charles

AU - Njunge, James

AU - Ngoi, Joyce

AU - Mutunga, Martin

AU - Chege, Timothy

AU - Gicheru, Elijah

AU - Gardiner, Elizabeth

AU - Gwela, Agnes

AU - Green, Christopher

AU - Drysdale, Simon

AU - Berkley, James

AU - Nokes, James

AU - Pollard, Andrew

PY - 2019/5/17

Y1 - 2019/5/17

N2 - RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics analysis we simultaneously analysed the microbiota and proteomes of the upper airway and determined direct antibacterial activity in airway secretions of RSV-infected children. Here, we report that the airway abundance of Streptococcus was higher in samples collected at the time of RSV infection compared with samples collected one month later. RSV infection is associated with neutrophil influx into the airway and degranulation and is marked by overexpression of proteins with known antibacterial activity including BPI, EPX, MPO and AZU1. Airway secretions of children infected with RSV, have significantly greater antibacterial activity compared to RSV-negative controls. This RSV-associated, neutrophil-mediated antibacterial response in the airway appears to act as a regulatory mechanism that modulates bacterial growth in the airways of RSV-infected children.

AB - RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics analysis we simultaneously analysed the microbiota and proteomes of the upper airway and determined direct antibacterial activity in airway secretions of RSV-infected children. Here, we report that the airway abundance of Streptococcus was higher in samples collected at the time of RSV infection compared with samples collected one month later. RSV infection is associated with neutrophil influx into the airway and degranulation and is marked by overexpression of proteins with known antibacterial activity including BPI, EPX, MPO and AZU1. Airway secretions of children infected with RSV, have significantly greater antibacterial activity compared to RSV-negative controls. This RSV-associated, neutrophil-mediated antibacterial response in the airway appears to act as a regulatory mechanism that modulates bacterial growth in the airways of RSV-infected children.

UR - http://www.scopus.com/inward/record.url?scp=85065829352&partnerID=8YFLogxK

U2 - 10.1038/s41467-019-10222-z

DO - 10.1038/s41467-019-10222-z

M3 - Article

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2218

ER -