TY - JOUR
T1 - Aggressive and devastating neuropathy: the consequence of untreated slow-onset type 1 diabetes
AU - Narendran, Partheepan
AU - Creely, SJ
AU - Syed, A
AU - Tesfaye, S
AU - Winer, J
AU - Singh, BM
PY - 2010/7/27
Y1 - 2010/7/27
N2 - Though type 1 diabetes (T1D) is described to be a disease of acute onset, there is strong evidence for a period of subclinical hyperglycaemia leading up to diagnosis. We describe two clinical cases with a prolonged and insidious onset of T1D, where neurological complications were present at the time of diagnosis. In both, there was an initial rapid and debilitating progression in neurological as well as other microvascular complications, but with a subsequent stabilization in complications over the next few years. These rare and unusual cases illustrate the variable nature of the natural history of T1D as well as its microvascular complications.
AB - Though type 1 diabetes (T1D) is described to be a disease of acute onset, there is strong evidence for a period of subclinical hyperglycaemia leading up to diagnosis. We describe two clinical cases with a prolonged and insidious onset of T1D, where neurological complications were present at the time of diagnosis. In both, there was an initial rapid and debilitating progression in neurological as well as other microvascular complications, but with a subsequent stabilization in complications over the next few years. These rare and unusual cases illustrate the variable nature of the natural history of T1D as well as its microvascular complications.
U2 - 10.1093/qjmed/hcq133
DO - 10.1093/qjmed/hcq133
M3 - Article
C2 - 20663807
SN - 1460-2393
JO - QJM
JF - QJM
ER -
