Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis.

S Harding; F Provot; JB Beuscart; Mark Cook; Arthur Bradwell; Stephanie Stringer; D White; Paul Cockwell; CA Hutchison

doi:10.1093/ndt/gfr019

Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis.

S Harding, F Provot, JB Beuscart, Mark Cook, Arthur Bradwell, Stephanie Stringer, D White, Paul Cockwell, CA Hutchison

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.

Original language	English
Pages (from-to)	1438
Number of pages	1
Journal	Nephrology, Dialysis, Transplantation
Volume	26
Issue number	4
DOIs	https://doi.org/10.1093/ndt/gfr019
Publication status	Published - 1 Apr 2011

Access to Document

10.1093/ndt/gfr019

Cite this

@article{d3eaf6205f13464cbcf1c84545412d76,

title = "Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis.",

abstract = "Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.",

author = "S Harding and F Provot and JB Beuscart and Mark Cook and Arthur Bradwell and Stephanie Stringer and D White and Paul Cockwell and CA Hutchison",

year = "2011",

month = apr,

day = "1",

doi = "10.1093/ndt/gfr019",

language = "English",

volume = "26",

pages = "1438",

journal = "Nephrology, Dialysis, Transplantation",

issn = "1460-2385",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis.

AU - Harding, S

AU - Provot, F

AU - Beuscart, JB

AU - Cook, Mark

AU - Bradwell, Arthur

AU - Stringer, Stephanie

AU - White, D

AU - Cockwell, Paul

AU - Hutchison, CA

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.

AB - Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.

U2 - 10.1093/ndt/gfr019

DO - 10.1093/ndt/gfr019

M3 - Article

C2 - 21406545

SN - 1460-2385

VL - 26

SP - 1438

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

IS - 4

ER -

Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis.

Abstract

Access to Document

Fingerprint

Cite this