Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis.

Research output: Contribution to journalArticle


  • S Harding
  • F Provot
  • JB Beuscart
  • Stephanie Stringer
  • D White
  • CA Hutchison


Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights above the cut-off of the dialyser. It is important for clinicians to be aware of FLC aggregates as a reason for failure to remove FLCs by this new modality.


Original languageEnglish
Pages (from-to)1438
Number of pages1
JournalNephrology, Dialysis, Transplantation
Issue number4
Publication statusPublished - 1 Apr 2011