TY - JOUR
T1 - Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes
T2 - A Seven Year Follow-up Study
AU - Cochran, Lisa
AU - Welham, Alice
AU - Oliver, Chris
AU - Arshad, Adam
AU - Moss, Joanna F
PY - 2019/6
Y1 - 2019/6
N2 - Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline.
AB - Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline.
KW - Age
KW - Autism spectrum disorder
KW - Behaviour
KW - Cornelia de Lange syndrome
KW - Cri du Chat syndrome
UR - http://www.scopus.com/inward/record.url?scp=85064347969&partnerID=8YFLogxK
U2 - 10.1007/s10803-019-03966-6
DO - 10.1007/s10803-019-03966-6
M3 - Article
C2 - 30941551
SN - 0162-3257
VL - 49
SP - 2476
EP - 2487
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 6
ER -