Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study

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@article{ca7b609ce18f4d74a39c802e924b3d9c,
title = "Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study",
abstract = "Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline.",
keywords = "Age, Autism spectrum disorder, Behaviour, Cornelia de Lange syndrome, Cri du Chat syndrome",
author = "Lisa Cochran and Alice Welham and Chris Oliver and Adam Arshad and Moss, {Joanna F}",
year = "2019",
month = "6",
doi = "10.1007/s10803-019-03966-6",
language = "English",
volume = "49",
pages = "2476--2487",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes

T2 - A Seven Year Follow-up Study

AU - Cochran, Lisa

AU - Welham, Alice

AU - Oliver, Chris

AU - Arshad, Adam

AU - Moss, Joanna F

PY - 2019/6

Y1 - 2019/6

N2 - Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline.

AB - Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline.

KW - Age

KW - Autism spectrum disorder

KW - Behaviour

KW - Cornelia de Lange syndrome

KW - Cri du Chat syndrome

UR - http://www.scopus.com/inward/record.url?scp=85064347969&partnerID=8YFLogxK

U2 - 10.1007/s10803-019-03966-6

DO - 10.1007/s10803-019-03966-6

M3 - Article

VL - 49

SP - 2476

EP - 2487

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

IS - 6

ER -