Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Birmingham B15 2TT, UK.
  • Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Birmingham, UK. akw12@le.ac.uk.
  • University of Leicester, Leicester, UK. akw12@le.ac.uk.
  • Centre for Cardiovascular Sciences; College of Medical and Dental Sciences; University of Birmingham; Birmingham UK
  • Institute of Cognitive Neuroscience, University College London

Abstract

Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline.

Details

Original languageEnglish
JournalJournal of Autism and Developmental Disorders
Early online date2 Apr 2019
Publication statusE-pub ahead of print - 2 Apr 2019

Keywords

  • Age, Autism spectrum disorder, Behaviour, Cornelia de Lange syndrome, Cri du Chat syndrome