Age-related Behavioural Change in Cornelia de Lange and Cri du Chat Syndromes: A Seven Year Follow-up Study
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
- Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Birmingham B15 2TT, UK.
- Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Birmingham, UK. email@example.com.
- University of Leicester, Leicester, UK. firstname.lastname@example.org.
- Centre for Cardiovascular Sciences; College of Medical and Dental Sciences; University of Birmingham; Birmingham UK
- Institute of Cognitive Neuroscience, University College London
Age-related behavioural change in Cornelia de Lange syndrome is poorly understood. We report a 7 year follow-up study of adaptive behaviour, autism spectrum disorder symptomatology, language skills and behavioural characteristics in 30 individuals with Cornelia de Lange syndrome, compared with 18 individuals with Cri du Chat syndrome. The proportion of individuals with Cornelia de Lange syndrome meeting criteria for autism spectrum disorder on the Autism Diagnostic Observation Schedule increased, although patterns of change were complex. For both syndrome groups, absolute levels of adaptive ability were stable and receptive language improved, suggesting that changes over time do not result from an overall decline in ability. Reliable change index scores indicate heterogeneity within both groups in the occurrence of improvement or decline.
|Number of pages||12|
|Journal||Journal of Autism and Developmental Disorders|
|Early online date||2 Apr 2019|
|Publication status||Published - Jun 2019|
- Age, Autism spectrum disorder, Behaviour, Cornelia de Lange syndrome, Cri du Chat syndrome