Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease

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Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. / Dietrich, Thomas; Jimenez, M; Krall Kaye, EA; Vokonas, PS; Garcia, RI.

In: Circulation, Vol. 117, No. 13, 01.04.2008, p. 1668-74.

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Dietrich, Thomas ; Jimenez, M ; Krall Kaye, EA ; Vokonas, PS ; Garcia, RI. / Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. In: Circulation. 2008 ; Vol. 117, No. 13. pp. 1668-74.

Bibtex

@article{68f33afaf2634dfea9f0f0939a605c7c,
title = "Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease",
abstract = "BACKGROUND: Several epidemiological studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent. METHODS AND RESULTS: We evaluated the association between clinical and radiographic measures of periodontitis, edentulism, and incident CHD (angina, myocardial infarction, or fatal CHD) among 1203 men in the VA Normative Aging and Dental Longitudinal Studies who were followed up with triennial comprehensive medical and dental examinations up to 35 years (median 24 years). Cox proportional hazards models with time-varying effects of exposure and potential confounders were fit. We found a significant dose-dependent association between periodontitis and CHD incidence among men <60 years of age (hazard ratio 2.12, 95% confidence interval 1.26 to 3.60 comparing highest versus lowest category of radiographic bone loss, P for trend=0.02), independent of age, body mass index, smoking, alcohol intake, diabetes mellitus, fasting glucose, total cholesterol, high-density lipoprotein cholesterol, triglycerides, hypertension, systolic and diastolic blood pressure, education, marital status, income, and occupation. No association was found among men > 60 years of age. Similar results were found when the sum of probing pocket depths was used as a measure of periodontitis. Among men > or = 60 years of age, edentulous men tended to have a higher risk of CHD than dentate men in the lowest bone loss (hazard ratio 1.61, 95% confidence interval 0.95 to 2.73) and lowest pocket depth (hazard ratio 1.72, 95% confidence interval 1.03 to 2.85) categories, independent of confounders. CONCLUSIONS: Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.",
keywords = "coronary disease, inflammation, infection, epidemiology, risk factors",
author = "Thomas Dietrich and M Jimenez and {Krall Kaye}, EA and PS Vokonas and RI Garcia",
year = "2008",
month = apr,
day = "1",
doi = "10.1161/CIRCULATIONAHA.107.711507",
language = "English",
volume = "117",
pages = "1668--74",
journal = "Circulation",
issn = "0009-7322",
publisher = "American Heart Association",
number = "13",

}

RIS

TY - JOUR

T1 - Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease

AU - Dietrich, Thomas

AU - Jimenez, M

AU - Krall Kaye, EA

AU - Vokonas, PS

AU - Garcia, RI

PY - 2008/4/1

Y1 - 2008/4/1

N2 - BACKGROUND: Several epidemiological studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent. METHODS AND RESULTS: We evaluated the association between clinical and radiographic measures of periodontitis, edentulism, and incident CHD (angina, myocardial infarction, or fatal CHD) among 1203 men in the VA Normative Aging and Dental Longitudinal Studies who were followed up with triennial comprehensive medical and dental examinations up to 35 years (median 24 years). Cox proportional hazards models with time-varying effects of exposure and potential confounders were fit. We found a significant dose-dependent association between periodontitis and CHD incidence among men <60 years of age (hazard ratio 2.12, 95% confidence interval 1.26 to 3.60 comparing highest versus lowest category of radiographic bone loss, P for trend=0.02), independent of age, body mass index, smoking, alcohol intake, diabetes mellitus, fasting glucose, total cholesterol, high-density lipoprotein cholesterol, triglycerides, hypertension, systolic and diastolic blood pressure, education, marital status, income, and occupation. No association was found among men > 60 years of age. Similar results were found when the sum of probing pocket depths was used as a measure of periodontitis. Among men > or = 60 years of age, edentulous men tended to have a higher risk of CHD than dentate men in the lowest bone loss (hazard ratio 1.61, 95% confidence interval 0.95 to 2.73) and lowest pocket depth (hazard ratio 1.72, 95% confidence interval 1.03 to 2.85) categories, independent of confounders. CONCLUSIONS: Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.

AB - BACKGROUND: Several epidemiological studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent. METHODS AND RESULTS: We evaluated the association between clinical and radiographic measures of periodontitis, edentulism, and incident CHD (angina, myocardial infarction, or fatal CHD) among 1203 men in the VA Normative Aging and Dental Longitudinal Studies who were followed up with triennial comprehensive medical and dental examinations up to 35 years (median 24 years). Cox proportional hazards models with time-varying effects of exposure and potential confounders were fit. We found a significant dose-dependent association between periodontitis and CHD incidence among men <60 years of age (hazard ratio 2.12, 95% confidence interval 1.26 to 3.60 comparing highest versus lowest category of radiographic bone loss, P for trend=0.02), independent of age, body mass index, smoking, alcohol intake, diabetes mellitus, fasting glucose, total cholesterol, high-density lipoprotein cholesterol, triglycerides, hypertension, systolic and diastolic blood pressure, education, marital status, income, and occupation. No association was found among men > 60 years of age. Similar results were found when the sum of probing pocket depths was used as a measure of periodontitis. Among men > or = 60 years of age, edentulous men tended to have a higher risk of CHD than dentate men in the lowest bone loss (hazard ratio 1.61, 95% confidence interval 0.95 to 2.73) and lowest pocket depth (hazard ratio 1.72, 95% confidence interval 1.03 to 2.85) categories, independent of confounders. CONCLUSIONS: Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.

KW - coronary disease

KW - inflammation

KW - infection

KW - epidemiology

KW - risk factors

U2 - 10.1161/CIRCULATIONAHA.107.711507

DO - 10.1161/CIRCULATIONAHA.107.711507

M3 - Article

C2 - 18362228

VL - 117

SP - 1668

EP - 1674

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 13

ER -