Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study

Research output: Contribution to journalArticlepeer-review


  • Shiu Lun Au Yeung
  • Chaoqiang Jiang
  • Lin Xu
  • Weisen Zhang
  • Tai Hing Lam
  • Gabriel Matthew Leung
  • C. Mary Schooling

Colleges, School and Institutes

External organisations

  • School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong
  • Guangzhou Number 12 Hospital, Guangzhou
  • City University of New York, Graduate School of Public Health and Health Policy


To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n=12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.


Original languageEnglish
JournalPsychiatry Research
Early online date19 Sep 2017
Publication statusE-pub ahead of print - 19 Sep 2017


  • China , epidemiology