Afferent visual manifestations of traumatic brain injury

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Afferent visual manifestations of traumatic brain injury. / Saliman, Noor Haziq; Belli, Antonio; Blanch, Richard.

In: Journal of Neurotrauma, Vol. 38, No. 20, 12.10.2021, p. 2778-2789.

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@article{4fb940c21f824b75afff13c8fbcc2768,
title = "Afferent visual manifestations of traumatic brain injury",
abstract = "Traumatic brain injury (TBI) causes structural and functional damage to the central nervous system including the visual pathway. Defects in the afferent visual pathways affect visual function and in severe cases cause complete visual loss. Visual dysfunction is detectable by structural and functional ophthalmic examinations that are routine in the eye clinic, including examination of the pupillary light reflex and optical coherence tomography (OCT). Assessment of pupillary light reflex is a non-invasive assessment combining afferent and efferent visual function. While a assessment using a flashlight is relatively insensitive, automated pupillometry has 95% specificity and 78.1% sensitivity in detecting TBI-related visual and cerebral dysfunction with an area under the curve of 0.69-0.78. OCT may also serve as a noninvasive biomarker of TBI severity, demonstrating changes in the retinal ganglion cell layer and nerve fiber layer throughout the range of TBI severity even in the absence of visual symptoms. This review discusses the impact of TBI on visual structure and function.",
keywords = "traumatic brain injury, adult brain injury, assessment tools, degeneration, head trauma, ganglion cell layer, optical coherent tomography, retinal nerve fiber layer, traumatic optic neuropathy, visual function",
author = "Saliman, {Noor Haziq} and Antonio Belli and Richard Blanch",
year = "2021",
month = oct,
day = "12",
doi = "10.1089/neu.2021.0182",
language = "English",
volume = "38",
pages = "2778--2789",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert",
number = "20",

}

RIS

TY - JOUR

T1 - Afferent visual manifestations of traumatic brain injury

AU - Saliman, Noor Haziq

AU - Belli, Antonio

AU - Blanch, Richard

PY - 2021/10/12

Y1 - 2021/10/12

N2 - Traumatic brain injury (TBI) causes structural and functional damage to the central nervous system including the visual pathway. Defects in the afferent visual pathways affect visual function and in severe cases cause complete visual loss. Visual dysfunction is detectable by structural and functional ophthalmic examinations that are routine in the eye clinic, including examination of the pupillary light reflex and optical coherence tomography (OCT). Assessment of pupillary light reflex is a non-invasive assessment combining afferent and efferent visual function. While a assessment using a flashlight is relatively insensitive, automated pupillometry has 95% specificity and 78.1% sensitivity in detecting TBI-related visual and cerebral dysfunction with an area under the curve of 0.69-0.78. OCT may also serve as a noninvasive biomarker of TBI severity, demonstrating changes in the retinal ganglion cell layer and nerve fiber layer throughout the range of TBI severity even in the absence of visual symptoms. This review discusses the impact of TBI on visual structure and function.

AB - Traumatic brain injury (TBI) causes structural and functional damage to the central nervous system including the visual pathway. Defects in the afferent visual pathways affect visual function and in severe cases cause complete visual loss. Visual dysfunction is detectable by structural and functional ophthalmic examinations that are routine in the eye clinic, including examination of the pupillary light reflex and optical coherence tomography (OCT). Assessment of pupillary light reflex is a non-invasive assessment combining afferent and efferent visual function. While a assessment using a flashlight is relatively insensitive, automated pupillometry has 95% specificity and 78.1% sensitivity in detecting TBI-related visual and cerebral dysfunction with an area under the curve of 0.69-0.78. OCT may also serve as a noninvasive biomarker of TBI severity, demonstrating changes in the retinal ganglion cell layer and nerve fiber layer throughout the range of TBI severity even in the absence of visual symptoms. This review discusses the impact of TBI on visual structure and function.

KW - traumatic brain injury

KW - adult brain injury

KW - assessment tools

KW - degeneration

KW - head trauma

KW - ganglion cell layer

KW - optical coherent tomography

KW - retinal nerve fiber layer

KW - traumatic optic neuropathy

KW - visual function

U2 - 10.1089/neu.2021.0182

DO - 10.1089/neu.2021.0182

M3 - Article

C2 - 34269619

VL - 38

SP - 2778

EP - 2789

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 20

ER -