Adverse effects of therapy for ANCA-associated vasculitis.

Jennifer Turnbull; Lorraine Harper

doi:10.1016/j.berh.2009.04.002

Adverse effects of therapy for ANCA-associated vasculitis.

Jennifer Turnbull, Lorraine Harper

Immunology and Immunotherapy

Research output: Contribution to journal › Article

40 Citations (Scopus)

Abstract

The introduction of cyclophosphamide- and prednisolone-based treatment regimens has significantly improved outcome in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis. However, these regimens are nonspecific immunosuppressants associated with significant toxicity, including increased risk of infection, leucopenia, diabetes and malignancy. In addition, disease damage, particularly renal failure, increases the risk of toxicity. Improvements in disease management should include the increased awareness of treatment-related toxicity and its prevention.

Original language	English
Pages (from-to)	391-401
Number of pages	11
Journal	Best Practice & Research: Clinical Rheumatology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.berh.2009.04.002
Publication status	Published - 1 Jun 2009

Keywords

immunosuppression
toxicity
adverse events
ANCA-associated vasculitis
infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.berh.2009.04.002

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abstract = "The introduction of cyclophosphamide- and prednisolone-based treatment regimens has significantly improved outcome in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis. However, these regimens are nonspecific immunosuppressants associated with significant toxicity, including increased risk of infection, leucopenia, diabetes and malignancy. In addition, disease damage, particularly renal failure, increases the risk of toxicity. Improvements in disease management should include the increased awareness of treatment-related toxicity and its prevention.",

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KW - immunosuppression

KW - toxicity

KW - adverse events

KW - ANCA-associated vasculitis

KW - infection

U2 - 10.1016/j.berh.2009.04.002

DO - 10.1016/j.berh.2009.04.002

M3 - Article

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SN - 1532-1770

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JO - Best Practice & Research: Clinical Rheumatology

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ER -

Adverse effects of therapy for ANCA-associated vasculitis.

Abstract

Keywords

UN SDGs

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