Advanced tools for the safety assessment of nanomaterials

Research output: Contribution to journalReview article

Authors

  • Bengt Fadeel
  • Lucian Farcal
  • Barry J. Hardy
  • Socorro Vázquez-Campos
  • Danail Hristozov
  • Antonio Marcomini
  • Harri Alenius
  • Kai Savolainen

Colleges, School and Institutes

External organisations

  • Karolinska Institute
  • University of Helsinki
  • Finnish Institute of Occupational Health (FIOH)
  • Douglas Connect GmbH
  • LEITAT Technology Centre
  • Ca' Foscari University of Venice

Abstract

Engineered nanomaterials (ENMs) have tremendous potential to produce beneficial technological impact in numerous sectors in society. Safety assessment is, of course, of paramount importance. However, the myriad variations of ENM properties makes the identification of specific features driving toxicity challenging. At the same time, reducing animal tests by introducing alternative and/or predictive in vitro and in silico methods has become a priority. It is important to embrace these new advances in the safety assessment of ENMs. Indeed, remarkable progress has been made in recent years with respect to mechanism-based hazard assessment of ENMs, including systems biology approaches as well as high-throughput screening platforms, and new tools are also emerging in risk assessment and risk management for humans and the environment across the whole life-cycle of nano-enabled products. Here, we highlight some of the key advances in the hazard and risk assessment of ENMs.

Details

Original languageEnglish
Pages (from-to)537-543
Number of pages7
JournalNature Nanotechnology
Volume13
Issue number7
Publication statusPublished - 6 Jul 2018

Keywords

  • Nanoscale materials, Nanotoxicology