Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis

H B Rasmussen; Marilyn Kelly; J Clausen

doi:10.1177/135245850100700203

Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis

H B Rasmussen, Marilyn Kelly, J Clausen

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Abstract

Multiple sclerosis (MS) has been associated with the human leukocyte antigen DR15 allele in Caucasians of North and Central European origin. However, the relative effect of the DR15 homozygous and the DR15 heterozygous genotypes on the disease susceptibility is unclear. Based upon results from three North European studies we have examined this by meta-analysis. Our results suggested that the effect of the DRB1*1501,DQA1*0102,DQB1*0602 haplotype on the susceptibility to MS is additive, perhaps reflecting that development of the disease is facilitated by a high density surface expression of the antigen presenting molecules encoded by this haplotype. Possible implications of our finding to future studies of the genetic background of MS is discussed.

Original language	English
Pages (from-to)	91-3
Number of pages	3
Journal	Multiple Sclerosis
Volume	7
Issue number	2
DOIs	https://doi.org/10.1177/135245850100700203
Publication status	Published - Apr 2001

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title = "Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis",

abstract = "Multiple sclerosis (MS) has been associated with the human leukocyte antigen DR15 allele in Caucasians of North and Central European origin. However, the relative effect of the DR15 homozygous and the DR15 heterozygous genotypes on the disease susceptibility is unclear. Based upon results from three North European studies we have examined this by meta-analysis. Our results suggested that the effect of the DRB1*1501,DQA1*0102,DQB1*0602 haplotype on the susceptibility to MS is additive, perhaps reflecting that development of the disease is facilitated by a high density surface expression of the antigen presenting molecules encoded by this haplotype. Possible implications of our finding to future studies of the genetic background of MS is discussed.",

author = "Rasmussen, {H B} and Marilyn Kelly and J Clausen",

year = "2001",

month = apr,

doi = "10.1177/135245850100700203",

language = "English",

volume = "7",

pages = "91--3",

journal = "Multiple Sclerosis",

issn = "1352-4585",

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number = "2",

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T1 - Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis

AU - Rasmussen, H B

AU - Kelly, Marilyn

AU - Clausen, J

PY - 2001/4

Y1 - 2001/4

N2 - Multiple sclerosis (MS) has been associated with the human leukocyte antigen DR15 allele in Caucasians of North and Central European origin. However, the relative effect of the DR15 homozygous and the DR15 heterozygous genotypes on the disease susceptibility is unclear. Based upon results from three North European studies we have examined this by meta-analysis. Our results suggested that the effect of the DRB1*1501,DQA1*0102,DQB1*0602 haplotype on the susceptibility to MS is additive, perhaps reflecting that development of the disease is facilitated by a high density surface expression of the antigen presenting molecules encoded by this haplotype. Possible implications of our finding to future studies of the genetic background of MS is discussed.

AB - Multiple sclerosis (MS) has been associated with the human leukocyte antigen DR15 allele in Caucasians of North and Central European origin. However, the relative effect of the DR15 homozygous and the DR15 heterozygous genotypes on the disease susceptibility is unclear. Based upon results from three North European studies we have examined this by meta-analysis. Our results suggested that the effect of the DRB1*1501,DQA1*0102,DQB1*0602 haplotype on the susceptibility to MS is additive, perhaps reflecting that development of the disease is facilitated by a high density surface expression of the antigen presenting molecules encoded by this haplotype. Possible implications of our finding to future studies of the genetic background of MS is discussed.

U2 - 10.1177/135245850100700203

DO - 10.1177/135245850100700203

M3 - Article

C2 - 11424637

SN - 1352-4585

VL - 7

SP - 91

EP - 93

JO - Multiple Sclerosis

JF - Multiple Sclerosis

IS - 2

ER -

Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis

Abstract

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