'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution

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'Add, stir and reduce' : Yersinia spp. as model bacteria for pathogen evolution. / McNally, Alan; Thomson, Nicholas R; Reuter, Sandra; Wren, Brendan W.

In: Nature Reviews Microbiology, Vol. 14, No. 3, 03.2016, p. 177-190.

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McNally, Alan ; Thomson, Nicholas R ; Reuter, Sandra ; Wren, Brendan W. / 'Add, stir and reduce' : Yersinia spp. as model bacteria for pathogen evolution. In: Nature Reviews Microbiology. 2016 ; Vol. 14, No. 3. pp. 177-190.

Bibtex

@article{deb3929ce4674ecc8d9aa4692b53f020,
title = "'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution",
abstract = "Pathogenic species in the Yersinia genus have historically been targets for research aimed at understanding how bacteria evolve into mammalian pathogens. The advent of large-scale population genomic studies has greatly accelerated the progress in this field, and Yersinia pestis, Yersinia pseudotuberculosis and Yersinia enterocolitica have once again acted as model organisms to help shape our understanding of the evolutionary processes involved in pathogenesis. In this Review, we highlight the gene gain, gene loss and genome rearrangement events that have been identified by genomic studies in pathogenic Yersinia species, and we discuss how these findings are changing our understanding of pathogen evolution. Finally, as these traits are also found in the genomes of other species in the Enterobacteriaceae, we suggest that they provide a blueprint for the evolution of enteropathogenic bacteria.",
keywords = "Animals, Enterobacteriaceae, Evolution, Molecular, Genome, Bacterial, Humans, Insect Vectors, Models, Molecular, Multigene Family, Phylogeny, Regulon, Yersinia, Yersinia Infections, Yersinia enterocolitica, Yersinia pestis, Yersinia pseudotuberculosis",
author = "Alan McNally and Thomson, {Nicholas R} and Sandra Reuter and Wren, {Brendan W}",
year = "2016",
month = mar
doi = "10.1038/nrmicro.2015.29",
language = "English",
volume = "14",
pages = "177--190",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "3",

}

RIS

TY - JOUR

T1 - 'Add, stir and reduce'

T2 - Yersinia spp. as model bacteria for pathogen evolution

AU - McNally, Alan

AU - Thomson, Nicholas R

AU - Reuter, Sandra

AU - Wren, Brendan W

PY - 2016/3

Y1 - 2016/3

N2 - Pathogenic species in the Yersinia genus have historically been targets for research aimed at understanding how bacteria evolve into mammalian pathogens. The advent of large-scale population genomic studies has greatly accelerated the progress in this field, and Yersinia pestis, Yersinia pseudotuberculosis and Yersinia enterocolitica have once again acted as model organisms to help shape our understanding of the evolutionary processes involved in pathogenesis. In this Review, we highlight the gene gain, gene loss and genome rearrangement events that have been identified by genomic studies in pathogenic Yersinia species, and we discuss how these findings are changing our understanding of pathogen evolution. Finally, as these traits are also found in the genomes of other species in the Enterobacteriaceae, we suggest that they provide a blueprint for the evolution of enteropathogenic bacteria.

AB - Pathogenic species in the Yersinia genus have historically been targets for research aimed at understanding how bacteria evolve into mammalian pathogens. The advent of large-scale population genomic studies has greatly accelerated the progress in this field, and Yersinia pestis, Yersinia pseudotuberculosis and Yersinia enterocolitica have once again acted as model organisms to help shape our understanding of the evolutionary processes involved in pathogenesis. In this Review, we highlight the gene gain, gene loss and genome rearrangement events that have been identified by genomic studies in pathogenic Yersinia species, and we discuss how these findings are changing our understanding of pathogen evolution. Finally, as these traits are also found in the genomes of other species in the Enterobacteriaceae, we suggest that they provide a blueprint for the evolution of enteropathogenic bacteria.

KW - Animals

KW - Enterobacteriaceae

KW - Evolution, Molecular

KW - Genome, Bacterial

KW - Humans

KW - Insect Vectors

KW - Models, Molecular

KW - Multigene Family

KW - Phylogeny

KW - Regulon

KW - Yersinia

KW - Yersinia Infections

KW - Yersinia enterocolitica

KW - Yersinia pestis

KW - Yersinia pseudotuberculosis

U2 - 10.1038/nrmicro.2015.29

DO - 10.1038/nrmicro.2015.29

M3 - Article

C2 - 26876035

VL - 14

SP - 177

EP - 190

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 3

ER -