Adapting to change: Interactions of Candida albicans with its environment

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

Abstract

Candida albicans is a commensal of the oral, gastrointestinal and genital tracts of
80% of the population. However, during periods of immune suppression C. albicans
is able to proliferate and damage the host. Infections range from chronic mucosal
infections to life threatening systemic disease. C. albicans is estimated to cause 75
million cases of genital thrush each year, with 5-15% of women developing recurrent infection [1], and 400,000 deaths each year due to disseminated disease [2]. During commensalism the fungus is exposed to a plethora of biotic and abiotic
environmental signals to which is must respond and adapt to, with many of these
environmental cues activating the expression of virulence factors.

Details

Original languageEnglish
JournalFuture Microbiology
Volume12
Issue number11
Early online date2 Aug 2017
Publication statusPublished - 1 Sep 2017

Keywords

  • Candida , cell wall , environmental sensing , host adaptation , morphogenesis , pH