Acute toxicity of Zinc Oxide nanoparticles to silkworm (Bombyx mori L.)

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Acute toxicity of Zinc Oxide nanoparticles to silkworm (Bombyx mori L.). / Xu, Yuanyuan; Wang, Wenrong; Ma, Lin; Cui, Xianjin; Lynch, Iseult; Wu, Guohua.

In: Chemosphere, Vol. 259, 03.07.2020, p. 127481.

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Xu, Yuanyuan ; Wang, Wenrong ; Ma, Lin ; Cui, Xianjin ; Lynch, Iseult ; Wu, Guohua. / Acute toxicity of Zinc Oxide nanoparticles to silkworm (Bombyx mori L.). In: Chemosphere. 2020 ; Vol. 259. pp. 127481.

Bibtex

@article{0b1827e0eaed491a95c29ae3ce0e49c7,
title = "Acute toxicity of Zinc Oxide nanoparticles to silkworm (Bombyx mori L.)",
abstract = "Zinc Oxide nanoparticles (ZnO NPs) has been heavily used in the industry, and increasing concerns on the ecotoxicity has arisen due to the risk of release into the environment. In this work, silkworm was used here as a model organism to study the toxicity of ZnO NPs, due to the presence of a conserved immune response as well as a pharmacokinetics similar to mammals. Zn accumulation, biodistribution and toxicity in silkworms were monitored at different time points after a subcutaneous injection. The highest cumulative content of ZnO NPs was detected in the midgut. The results of catalytic activity studies confirmed that the antioxidant enzymes (SOD, CAT, GSH-PX) in midgut cells were expressed in response to ZnO NPs. The expression of genes (Dronc and Caspase-1) related to apoptosis was increased, while the Trt gene was down-regulated. A possible mechanism was proposed for toxicity of ZnO NPs to silkworms.",
author = "Yuanyuan Xu and Wenrong Wang and Lin Ma and Xianjin Cui and Iseult Lynch and Guohua Wu",
note = "Copyright {\textcopyright} 2020 Elsevier Ltd. All rights reserved.",
year = "2020",
month = jul,
day = "3",
doi = "10.1016/j.chemosphere.2020.127481",
language = "English",
volume = "259",
pages = "127481",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Acute toxicity of Zinc Oxide nanoparticles to silkworm (Bombyx mori L.)

AU - Xu, Yuanyuan

AU - Wang, Wenrong

AU - Ma, Lin

AU - Cui, Xianjin

AU - Lynch, Iseult

AU - Wu, Guohua

N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.

PY - 2020/7/3

Y1 - 2020/7/3

N2 - Zinc Oxide nanoparticles (ZnO NPs) has been heavily used in the industry, and increasing concerns on the ecotoxicity has arisen due to the risk of release into the environment. In this work, silkworm was used here as a model organism to study the toxicity of ZnO NPs, due to the presence of a conserved immune response as well as a pharmacokinetics similar to mammals. Zn accumulation, biodistribution and toxicity in silkworms were monitored at different time points after a subcutaneous injection. The highest cumulative content of ZnO NPs was detected in the midgut. The results of catalytic activity studies confirmed that the antioxidant enzymes (SOD, CAT, GSH-PX) in midgut cells were expressed in response to ZnO NPs. The expression of genes (Dronc and Caspase-1) related to apoptosis was increased, while the Trt gene was down-regulated. A possible mechanism was proposed for toxicity of ZnO NPs to silkworms.

AB - Zinc Oxide nanoparticles (ZnO NPs) has been heavily used in the industry, and increasing concerns on the ecotoxicity has arisen due to the risk of release into the environment. In this work, silkworm was used here as a model organism to study the toxicity of ZnO NPs, due to the presence of a conserved immune response as well as a pharmacokinetics similar to mammals. Zn accumulation, biodistribution and toxicity in silkworms were monitored at different time points after a subcutaneous injection. The highest cumulative content of ZnO NPs was detected in the midgut. The results of catalytic activity studies confirmed that the antioxidant enzymes (SOD, CAT, GSH-PX) in midgut cells were expressed in response to ZnO NPs. The expression of genes (Dronc and Caspase-1) related to apoptosis was increased, while the Trt gene was down-regulated. A possible mechanism was proposed for toxicity of ZnO NPs to silkworms.

U2 - 10.1016/j.chemosphere.2020.127481

DO - 10.1016/j.chemosphere.2020.127481

M3 - Article

C2 - 32650163

VL - 259

SP - 127481

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

ER -