Acute ingestion of red wine by men activates platelets but does not influence endothelial markers: no effect of white wine

Research output: Contribution to journalArticle


  • Andrew Blann
  • NR Williams
  • Gregory Lip
  • J Rajput-Williams
  • AN Howard

Colleges, School and Institutes


Long-term moderate alcohol use is associated with a better cardiovascular risk profile than total abstinence, although the short-term effect of a bolus of alcohol is unclear. The hypothesis tested in this study was that an acute bolus of alcohol would adversely affect the endothelium and platelets. Blood was taken before and 4 h after the ingestion of red or white wine by nine volunteers per group, and by 11 control water-only drinkers at the same time points. Plasma was obtained and markers of platelet activity (beta-thromboglobulin and soluble P selectin) and endothelial cell function (von Willebrand factor and soluble thrombomodulin) measured by enzyme-linked immunosorbent assay. The only marker to change significantly was beta-thromboglobulin, which increased from a median of 10 ng/ml (interquartile range, 8.5-15) before drinking red wine to 16 ng/ml (interquartile range, 14-20) 4 h later (P = 0.0067). We conclude that an acute bolus of red wine, but not white wine, activates platelets but has no substantial effect on the endothelium.


Original languageEnglish
Pages (from-to)647-651
Number of pages5
JournalBlood Coagulation and Fibrinolysis
Publication statusPublished - 1 Jan 2002