Activity of faropenem for ciprofloxacin-resistant bacteria

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Activity of faropenem for ciprofloxacin-resistant bacteria. / Piddock, Laura; Johnson, Margaret; Webber, Mark.

In: Journal of Antimicrobial Chemotherapy, Vol. 52, No. 3, 13.08.2003, p. 500-2.

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@article{196fd1b142df4f9b9fe084623afb0edb,
title = "Activity of faropenem for ciprofloxacin-resistant bacteria",
abstract = "AIM: To determine whether an association exists between ciprofloxacin and faropenem resistance in bacteria including multiply drug-resistant isolates. METHODS: The MICs were determined for 150 fluoroquinolone-resistant bacteria, plus 20 nalidixic acid-resistant strains of Salmonella enterica serovar Typhimurium. RESULTS: Faropenem was very active against Escherichia coli and Streptococcus pneumoniae, but 5/31 Staphylococcus aureus and 2/26 Bacteroides fragilis required > or =16 mg/L for inhibition. Of 30 multiply drug-resistant isolates with a phenotype suggestive of enhanced efflux, only for one strain (a Bacteroides fragilis) was the faropenem MIC higher than that associated with the other isolates of the same species. CONCLUSIONS: Faropenem was in general as active as imipenem. There was no association between resistance to ciprofloxacin and faropenem or imipenem resistance.",
keywords = "fluoroquinolone, MIC, carbapenem",
author = "Laura Piddock and Margaret Johnson and Mark Webber",
year = "2003",
month = aug,
day = "13",
doi = "10.1093/jac/dkg373",
language = "English",
volume = "52",
pages = "500--2",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Activity of faropenem for ciprofloxacin-resistant bacteria

AU - Piddock, Laura

AU - Johnson, Margaret

AU - Webber, Mark

PY - 2003/8/13

Y1 - 2003/8/13

N2 - AIM: To determine whether an association exists between ciprofloxacin and faropenem resistance in bacteria including multiply drug-resistant isolates. METHODS: The MICs were determined for 150 fluoroquinolone-resistant bacteria, plus 20 nalidixic acid-resistant strains of Salmonella enterica serovar Typhimurium. RESULTS: Faropenem was very active against Escherichia coli and Streptococcus pneumoniae, but 5/31 Staphylococcus aureus and 2/26 Bacteroides fragilis required > or =16 mg/L for inhibition. Of 30 multiply drug-resistant isolates with a phenotype suggestive of enhanced efflux, only for one strain (a Bacteroides fragilis) was the faropenem MIC higher than that associated with the other isolates of the same species. CONCLUSIONS: Faropenem was in general as active as imipenem. There was no association between resistance to ciprofloxacin and faropenem or imipenem resistance.

AB - AIM: To determine whether an association exists between ciprofloxacin and faropenem resistance in bacteria including multiply drug-resistant isolates. METHODS: The MICs were determined for 150 fluoroquinolone-resistant bacteria, plus 20 nalidixic acid-resistant strains of Salmonella enterica serovar Typhimurium. RESULTS: Faropenem was very active against Escherichia coli and Streptococcus pneumoniae, but 5/31 Staphylococcus aureus and 2/26 Bacteroides fragilis required > or =16 mg/L for inhibition. Of 30 multiply drug-resistant isolates with a phenotype suggestive of enhanced efflux, only for one strain (a Bacteroides fragilis) was the faropenem MIC higher than that associated with the other isolates of the same species. CONCLUSIONS: Faropenem was in general as active as imipenem. There was no association between resistance to ciprofloxacin and faropenem or imipenem resistance.

KW - fluoroquinolone

KW - MIC

KW - carbapenem

UR - http://www.scopus.com/inward/record.url?scp=0141852767&partnerID=8YFLogxK

U2 - 10.1093/jac/dkg373

DO - 10.1093/jac/dkg373

M3 - Article

C2 - 12917244

VL - 52

SP - 500

EP - 502

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 3

ER -