Activity of faropenem for ciprofloxacin-resistant bacteria

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

AIM: To determine whether an association exists between ciprofloxacin and faropenem resistance in bacteria including multiply drug-resistant isolates. METHODS: The MICs were determined for 150 fluoroquinolone-resistant bacteria, plus 20 nalidixic acid-resistant strains of Salmonella enterica serovar Typhimurium. RESULTS: Faropenem was very active against Escherichia coli and Streptococcus pneumoniae, but 5/31 Staphylococcus aureus and 2/26 Bacteroides fragilis required > or =16 mg/L for inhibition. Of 30 multiply drug-resistant isolates with a phenotype suggestive of enhanced efflux, only for one strain (a Bacteroides fragilis) was the faropenem MIC higher than that associated with the other isolates of the same species. CONCLUSIONS: Faropenem was in general as active as imipenem. There was no association between resistance to ciprofloxacin and faropenem or imipenem resistance.

Details

Original languageEnglish
Pages (from-to)500-2
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume52
Issue number3
Early online date13 Aug 2003
Publication statusPublished - 13 Aug 2003

Keywords

  • fluoroquinolone, MIC, carbapenem