Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
The activity of six cephalosporins, six penicillins and one monobactam combined with BRL 42715, clavulanic acid, sulbactam or tazobactam at 0.1, 0.5, 1, 2, 5 and 10 mg/L was determined for 45 beta-lactamase producing Gram-negative bacteria. The combination of BRL 42715 with any of the agents was more active than any of the other inhibitor and beta-lactam combinations. Unlike the other beta-lactamase inhibitors, BRL 42715 enhanced the activity of the beta-lactams for strains that constitutively expressed Richmond & Sykes Class I beta-lactamase and against strains expressing extended-spectrum plasmid-mediated beta-lactamases.
|Number of pages||15|
|Journal||Journal of Antimicrobial Chemotherapy|
|Publication status||Published - Jan 1993|
- Anti-Bacterial Agents, Clavulanic Acid, Clavulanic Acids, Drug Therapy, Combination, Enzyme Inhibitors, Gram-Negative Bacteria, Lactams, Penicillanic Acid, Sulbactam, beta-Lactamases, beta-Lactams