Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

Abstract

The activity of six cephalosporins, six penicillins and one monobactam combined with BRL 42715, clavulanic acid, sulbactam or tazobactam at 0.1, 0.5, 1, 2, 5 and 10 mg/L was determined for 45 beta-lactamase producing Gram-negative bacteria. The combination of BRL 42715 with any of the agents was more active than any of the other inhibitor and beta-lactam combinations. Unlike the other beta-lactamase inhibitors, BRL 42715 enhanced the activity of the beta-lactams for strains that constitutively expressed Richmond & Sykes Class I beta-lactamase and against strains expressing extended-spectrum plasmid-mediated beta-lactamases.

Details

Original languageEnglish
Pages (from-to)89-103
Number of pages15
JournalJournal of Antimicrobial Chemotherapy
Volume31
Issue number1
Publication statusPublished - Jan 1993

Keywords

  • Anti-Bacterial Agents, Clavulanic Acid, Clavulanic Acids, Drug Therapy, Combination, Enzyme Inhibitors, Gram-Negative Bacteria, Lactams, Penicillanic Acid, Sulbactam, beta-Lactamases, beta-Lactams