Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam

Research output: Contribution to journalArticlepeer-review


Colleges, School and Institutes


The activity of six cephalosporins, six penicillins and one monobactam combined with BRL 42715, clavulanic acid, sulbactam or tazobactam at 0.1, 0.5, 1, 2, 5 and 10 mg/L was determined for 45 beta-lactamase producing Gram-negative bacteria. The combination of BRL 42715 with any of the agents was more active than any of the other inhibitor and beta-lactam combinations. Unlike the other beta-lactamase inhibitors, BRL 42715 enhanced the activity of the beta-lactams for strains that constitutively expressed Richmond & Sykes Class I beta-lactamase and against strains expressing extended-spectrum plasmid-mediated beta-lactamases.


Original languageEnglish
Pages (from-to)89-103
Number of pages15
JournalJournal of Antimicrobial Chemotherapy
Issue number1
Publication statusPublished - Jan 1993


  • Anti-Bacterial Agents, Clavulanic Acid, Clavulanic Acids, Drug Therapy, Combination, Enzyme Inhibitors, Gram-Negative Bacteria, Lactams, Penicillanic Acid, Sulbactam, beta-Lactamases, beta-Lactams