Activation of the NO-cGMP signalling pathway depresses hippocampal synaptic transmission through an adenosine receptor-dependent mechanism

M. R. Broome; G. L. Collingridge; A. J. Irving

doi:10.1016/0028-3908(94)90056-6

Activation of the NO-cGMP signalling pathway depresses hippocampal synaptic transmission through an adenosine receptor-dependent mechanism

M. R. Broome^*, G. L. Collingridge, A. J. Irving

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Activation of the NO-cGMP pathway or adenosine receptors depresses reversibly synaptic transmission in the hippocampus. Here we demonstrate, using the selective A1 receptor antagonist DPCPX, a convergence in the mechanisms of action of the NO donor SNAP, the cGMP phosphodiesterase inhibitor zaprinast and adenosine.

Original language	English
Pages (from-to)	1511-1513
Number of pages	3
Journal	Neuropharmacology
Volume	33
Issue number	11
DOIs	https://doi.org/10.1016/0028-3908(94)90056-6
Publication status	Published - Nov 1994

Keywords

adenosine
cGMP
DPCPX
Nitric oxide
SNAP
zaprinast

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(94)90056-6

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abstract = "Activation of the NO-cGMP pathway or adenosine receptors depresses reversibly synaptic transmission in the hippocampus. Here we demonstrate, using the selective A1 receptor antagonist DPCPX, a convergence in the mechanisms of action of the NO donor SNAP, the cGMP phosphodiesterase inhibitor zaprinast and adenosine.",

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AB - Activation of the NO-cGMP pathway or adenosine receptors depresses reversibly synaptic transmission in the hippocampus. Here we demonstrate, using the selective A1 receptor antagonist DPCPX, a convergence in the mechanisms of action of the NO donor SNAP, the cGMP phosphodiesterase inhibitor zaprinast and adenosine.

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KW - cGMP

KW - DPCPX

KW - Nitric oxide

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Activation of the NO-cGMP signalling pathway depresses hippocampal synaptic transmission through an adenosine receptor-dependent mechanism

Abstract

Keywords

ASJC Scopus subject areas

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