Activation of the NO-cGMP signalling pathway depresses hippocampal synaptic transmission through an adenosine receptor-dependent mechanism

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • Department of Pharmacology
  • Birmingham University

Abstract

Activation of the NO-cGMP pathway or adenosine receptors depresses reversibly synaptic transmission in the hippocampus. Here we demonstrate, using the selective A1 receptor antagonist DPCPX, a convergence in the mechanisms of action of the NO donor SNAP, the cGMP phosphodiesterase inhibitor zaprinast and adenosine.

Details

Original languageEnglish
Pages (from-to)1511-1513
Number of pages3
JournalNeuropharmacology
Volume33
Issue number11
Publication statusPublished - Nov 1994

Keywords

  • adenosine, cGMP, DPCPX, Nitric oxide, SNAP, zaprinast