Acetylcholinesterase Activity Measurement and Clinical Features of Delirium

Thomas A Jackson; Hannah C Moorey; Bart Sheehan; Alasdair M J Maclullich; John R Gladman; Janet M Lord

doi:10.1159/000452832

Acetylcholinesterase Activity Measurement and Clinical Features of Delirium

Thomas A Jackson, Hannah C Moorey, Bart Sheehan, Alasdair M J Maclullich, John R Gladman, Janet M Lord

Inflammation and Ageing

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Abstract

AIMS: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum acetylcholinesterase (AChE) activity and (1) clinical features of delirium and (2) outcomes among older hospital patients with delirium.

METHODS: Hospitalised patients with delirium were recruited, and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay.

RESULTS: The mean AChE activity for the whole sample was 2.46 μmol/μL/min (standard deviation 1.75). Higher AChE activity was associated with increased likelihood of hypoactive delirium rather than the hyperactive or mixed subtype (odds ratio 1.98, 95% confidence interval 1.10-3.59).

CONCLUSION: Higher AChE activity was associated with hypoactive delirium but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	Dementia and Geriatric Cognitive Disorders
Volume	43
Issue number	1-2
Early online date	15 Dec 2016
DOIs	https://doi.org/10.1159/000452832
Publication status	Published - 2017

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10.1159/000452832

Jackson_et_al_Acetylcholinesterase_Activity_Measurement_ Dementia_Geriatric_Cognitive_Disorders
Final Version of Record available at: http://dx.doi.org/10.1159/000452832 Checked 16/12/2016
Accepted author manuscript, 84.6 KBLicence: None: All rights reserved

Delirium in General Hospital as a Marker of Undiagnosed Dementia: Evaluation of Pragmatic Methods for Screening and Follow-Up
Jackson, T. & Lord, J.
AGE UK
19/09/12 → 30/09/16
Project: Research

Cite this

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title = "Acetylcholinesterase Activity Measurement and Clinical Features of Delirium",

abstract = "AIMS: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum acetylcholinesterase (AChE) activity and (1) clinical features of delirium and (2) outcomes among older hospital patients with delirium.METHODS: Hospitalised patients with delirium were recruited, and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay.RESULTS: The mean AChE activity for the whole sample was 2.46 μmol/μL/min (standard deviation 1.75). Higher AChE activity was associated with increased likelihood of hypoactive delirium rather than the hyperactive or mixed subtype (odds ratio 1.98, 95% confidence interval 1.10-3.59).CONCLUSION: Higher AChE activity was associated with hypoactive delirium but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium.",

author = "Jackson, {Thomas A} and Moorey, {Hannah C} and Bart Sheehan and Maclullich, {Alasdair M J} and Gladman, {John R} and Lord, {Janet M}",

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T1 - Acetylcholinesterase Activity Measurement and Clinical Features of Delirium

AU - Jackson, Thomas A

AU - Moorey, Hannah C

AU - Sheehan, Bart

AU - Maclullich, Alasdair M J

AU - Gladman, John R

AU - Lord, Janet M

PY - 2017

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N2 - AIMS: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum acetylcholinesterase (AChE) activity and (1) clinical features of delirium and (2) outcomes among older hospital patients with delirium.METHODS: Hospitalised patients with delirium were recruited, and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay.RESULTS: The mean AChE activity for the whole sample was 2.46 μmol/μL/min (standard deviation 1.75). Higher AChE activity was associated with increased likelihood of hypoactive delirium rather than the hyperactive or mixed subtype (odds ratio 1.98, 95% confidence interval 1.10-3.59).CONCLUSION: Higher AChE activity was associated with hypoactive delirium but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium.

AB - AIMS: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum acetylcholinesterase (AChE) activity and (1) clinical features of delirium and (2) outcomes among older hospital patients with delirium.METHODS: Hospitalised patients with delirium were recruited, and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay.RESULTS: The mean AChE activity for the whole sample was 2.46 μmol/μL/min (standard deviation 1.75). Higher AChE activity was associated with increased likelihood of hypoactive delirium rather than the hyperactive or mixed subtype (odds ratio 1.98, 95% confidence interval 1.10-3.59).CONCLUSION: Higher AChE activity was associated with hypoactive delirium but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium.

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JO - Dementia and Geriatric Cognitive Disorders

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Acetylcholinesterase Activity Measurement and Clinical Features of Delirium

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Delirium in General Hospital as a Marker of Undiagnosed Dementia: Evaluation of Pragmatic Methods for Screening and Follow-Up

Cite this