Accumulation of five fluoroquinolones by Mycobacterium tuberculosis H37R

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Abstract

The accumulation of ciprofloxacin, norfloxacin, moxifloxacin, levofloxacin and ofloxacin by Mycobacterium tuberculosis H37Rv was determined with a modified fluorescence method. The time to achieve a steady-state concentration (SSC) of each agent in M. tuberculosis was 60-240 s. Moxifloxacin was accumulated to the lowest concentration and ciprofloxacin to the highest. However, ciprofloxacin took longer to achieve an SSC than the other four agents; levofloxacin reached steady state in the shortest time. Larger fluoroquinolones accumulated to the lowest concentration and more slowly. Although all five agents had low hydrophobicity values (P(app) <or =0.11), those with the lowest values accumulated to the higher concentrations.

Details

Original languageEnglish
Pages (from-to)787-91
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume48
Issue number6
Publication statusPublished - 1 Dec 2001