Accumulation of 1,2-diacylglycerol in the plasma membrane may lead to echinocyte transformation of erythrocytes

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Accumulation of 1,2-diacylglycerol in the plasma membrane may lead to echinocyte transformation of erythrocytes. / Allan, David; Michell, Robert H.

In: Nature, Vol. 258, No. 5533, 01.12.1975, p. 348-349.

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@article{9d7357ba1c0f4ebda16db09050253386,
title = "Accumulation of 1,2-diacylglycerol in the plasma membrane may lead to echinocyte transformation of erythrocytes",
abstract = "THE change in shape of erythrocytes from the normal biconcave disk to a spiculed sphere (echinocyte1) can be caused by an increased intracellular concentration of Ca2+ (refs 2 to 5). We have found that an immediate biochemical effect of raising intracellular [Ca2+] is to increase the production of 1,2-diacylglycerol and cause its accumulation in the plasma membrane. This change in membrane composition may alter the structure of the membrane and thus cause the change in shape. Energy-depleted cells also show increased 1,2-diacylglycerol and similar but less extreme morphological changes, even in the absence of Ca2+.",
author = "David Allan and Michell, {Robert H.}",
year = "1975",
month = dec,
day = "1",
doi = "10.1038/258348a0",
language = "English",
volume = "258",
pages = "348--349",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5533",

}

RIS

TY - JOUR

T1 - Accumulation of 1,2-diacylglycerol in the plasma membrane may lead to echinocyte transformation of erythrocytes

AU - Allan, David

AU - Michell, Robert H.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - THE change in shape of erythrocytes from the normal biconcave disk to a spiculed sphere (echinocyte1) can be caused by an increased intracellular concentration of Ca2+ (refs 2 to 5). We have found that an immediate biochemical effect of raising intracellular [Ca2+] is to increase the production of 1,2-diacylglycerol and cause its accumulation in the plasma membrane. This change in membrane composition may alter the structure of the membrane and thus cause the change in shape. Energy-depleted cells also show increased 1,2-diacylglycerol and similar but less extreme morphological changes, even in the absence of Ca2+.

AB - THE change in shape of erythrocytes from the normal biconcave disk to a spiculed sphere (echinocyte1) can be caused by an increased intracellular concentration of Ca2+ (refs 2 to 5). We have found that an immediate biochemical effect of raising intracellular [Ca2+] is to increase the production of 1,2-diacylglycerol and cause its accumulation in the plasma membrane. This change in membrane composition may alter the structure of the membrane and thus cause the change in shape. Energy-depleted cells also show increased 1,2-diacylglycerol and similar but less extreme morphological changes, even in the absence of Ca2+.

UR - http://www.scopus.com/inward/record.url?scp=0016830799&partnerID=8YFLogxK

U2 - 10.1038/258348a0

DO - 10.1038/258348a0

M3 - Article

C2 - 1105194

AN - SCOPUS:0016830799

VL - 258

SP - 348

EP - 349

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5533

ER -