Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Research output: Contribution to journalArticlepeer-review

Authors

  • F G Riepe
  • S N Krüger
  • F C G J Sweep
  • J W M Lenders
  • J Dötsch
  • H Mönig
  • W G Sippell
  • C-J Partsch

Abstract

Patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency suffer from glucocorticoid and mineralocorticoid deficiency. They have insufficient epinephrine reserves and increased basal leptin levels and are often insulin resistant. In healthy subjects, an inhibitory effect of acute catecholamine elevation on the leptin plasma concentrations has been reported. However, it is not yet known how leptin levels respond to exercise in CAH patients.

Details

Original languageEnglish
Pages (from-to)105-10
Number of pages6
JournalExperimental and Clinical Endocrinology and Diabetes
Volume114
Issue number3
Publication statusPublished - 2006