Abrupt disintegration of highly porous particles in early stage dissolution

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@article{1de93b2700324eb1b4c2c6acc27d28ef,
title = "Abrupt disintegration of highly porous particles in early stage dissolution",
abstract = "Dissolution of highly porous particles is a ubiquitous process in formulation chemistry. Scientific challenges remain unsolved due to the complex of interfacial properties and physical interactions between solid, liquid and gas phases. Two spray-dried powders consisting of sodium sulphate and linear alkylbenzene sulfonate (LAS) were used to investigate the abrupt disintegration mechanism focusing on the residual air in the highly porous particle during wetting stage. Four typical dissolution phenomena were identified through individual particle dissolution experiments using optical microscopy. The images suggest for the first time a link between abrupt disintegration phenomenon and air behaviour. We have examined the hypothesis that, as well as chemical changes occurring during wetting, physical processes can lead to disintegration. Tensile tests of individual particles in both dry and hydrated conditions show significant weakening of the particle strength during hydration. Mathematical simulation shows that fast penetration of water through the open-ended pores compresses entrapped air and increases the internal pressure. Hoop stresses generated by internal pressure are of the same magnitude as breaking forces, suggesting that abrupt disintegration in the early stage of dissolution is driven by air compression.",
keywords = "abrupt disintegration , capillary action , X-ray microtomography , tensile strength",
author = "Hui Cao and Dimitris Karampalis and Yongliang Li and Joel Caragay and Alessio Alexiadis and Zhibing Zhang and Peter Fryer and Serafim Bakalis",
year = "2018",
month = jun
day = "15",
doi = "10.1016/j.powtec.2018.04.037",
language = "English",
volume = "333",
pages = "394--403",
journal = "Powder Technology",
issn = "0032-5910",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Abrupt disintegration of highly porous particles in early stage dissolution

AU - Cao, Hui

AU - Karampalis, Dimitris

AU - Li, Yongliang

AU - Caragay, Joel

AU - Alexiadis, Alessio

AU - Zhang, Zhibing

AU - Fryer, Peter

AU - Bakalis, Serafim

PY - 2018/6/15

Y1 - 2018/6/15

N2 - Dissolution of highly porous particles is a ubiquitous process in formulation chemistry. Scientific challenges remain unsolved due to the complex of interfacial properties and physical interactions between solid, liquid and gas phases. Two spray-dried powders consisting of sodium sulphate and linear alkylbenzene sulfonate (LAS) were used to investigate the abrupt disintegration mechanism focusing on the residual air in the highly porous particle during wetting stage. Four typical dissolution phenomena were identified through individual particle dissolution experiments using optical microscopy. The images suggest for the first time a link between abrupt disintegration phenomenon and air behaviour. We have examined the hypothesis that, as well as chemical changes occurring during wetting, physical processes can lead to disintegration. Tensile tests of individual particles in both dry and hydrated conditions show significant weakening of the particle strength during hydration. Mathematical simulation shows that fast penetration of water through the open-ended pores compresses entrapped air and increases the internal pressure. Hoop stresses generated by internal pressure are of the same magnitude as breaking forces, suggesting that abrupt disintegration in the early stage of dissolution is driven by air compression.

AB - Dissolution of highly porous particles is a ubiquitous process in formulation chemistry. Scientific challenges remain unsolved due to the complex of interfacial properties and physical interactions between solid, liquid and gas phases. Two spray-dried powders consisting of sodium sulphate and linear alkylbenzene sulfonate (LAS) were used to investigate the abrupt disintegration mechanism focusing on the residual air in the highly porous particle during wetting stage. Four typical dissolution phenomena were identified through individual particle dissolution experiments using optical microscopy. The images suggest for the first time a link between abrupt disintegration phenomenon and air behaviour. We have examined the hypothesis that, as well as chemical changes occurring during wetting, physical processes can lead to disintegration. Tensile tests of individual particles in both dry and hydrated conditions show significant weakening of the particle strength during hydration. Mathematical simulation shows that fast penetration of water through the open-ended pores compresses entrapped air and increases the internal pressure. Hoop stresses generated by internal pressure are of the same magnitude as breaking forces, suggesting that abrupt disintegration in the early stage of dissolution is driven by air compression.

KW - abrupt disintegration

KW - capillary action

KW - X-ray microtomography

KW - tensile strength

U2 - 10.1016/j.powtec.2018.04.037

DO - 10.1016/j.powtec.2018.04.037

M3 - Article

VL - 333

SP - 394

EP - 403

JO - Powder Technology

JF - Powder Technology

SN - 0032-5910

ER -