A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

David Reich; Nick Patterson; Philip L De Jager; Gavin J McDonald; Alicja Waliszewska; Arti Tandon; Robin R Lincoln; Cari DeLoa; Scott A Fruhan; Philippe Cabre; Odile Bera; Gilbert Semana; M Ann Kelly; David A Francis; Kristin Ardlie; Omar Khan; Bruce A C Cree; Stephen L Hauser; Jorge R Oksenberg; David A Hafler; Marilyn Kelly

doi:10.1038/ng1646

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

David Reich, Nick Patterson, Philip L De Jager, Gavin J McDonald, Alicja Waliszewska, Arti Tandon, Robin R Lincoln, Cari DeLoa, Scott A Fruhan, Philippe Cabre, Odile Bera, Gilbert Semana, M Ann Kelly, David A Francis, Kristin Ardlie, Omar Khan, Bruce A C Cree, Stephen L Hauser, Jorge R Oksenberg, David A HaflerMarilyn Kelly

Electronic, Electrical and Systems Engineering

Research output: Contribution to journal › Article › peer-review

221 Citations (Scopus)

Abstract

Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.

Original language	English
Pages (from-to)	1113-8
Number of pages	6
Journal	Nature Genetics
Volume	37
Issue number	10
DOIs	https://doi.org/10.1038/ng1646
Publication status	Published - 2005

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Reich, D., Patterson, N., De Jager, P. L., McDonald, G. J., Waliszewska, A., Tandon, A., Lincoln, R. R., DeLoa, C., Fruhan, S. A., Cabre, P., Bera, O., Semana, G., Kelly, M. A., Francis, D. A., Ardlie, K., Khan, O., Cree, B. A. C., Hauser, S. L., Oksenberg, J. R., ... Kelly, M. (2005). A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nature Genetics, 37(10), 1113-8. https://doi.org/10.1038/ng1646

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title = "A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility",

abstract = "Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.",

author = "David Reich and Nick Patterson and {De Jager}, {Philip L} and McDonald, {Gavin J} and Alicja Waliszewska and Arti Tandon and Lincoln, {Robin R} and Cari DeLoa and Fruhan, {Scott A} and Philippe Cabre and Odile Bera and Gilbert Semana and Kelly, {M Ann} and Francis, {David A} and Kristin Ardlie and Omar Khan and Cree, {Bruce A C} and Hauser, {Stephen L} and Oksenberg, {Jorge R} and Hafler, {David A} and Marilyn Kelly",

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doi = "10.1038/ng1646",

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Reich, D, Patterson, N, De Jager, PL, McDonald, GJ, Waliszewska, A, Tandon, A, Lincoln, RR, DeLoa, C, Fruhan, SA, Cabre, P, Bera, O, Semana, G, Kelly, MA, Francis, DA, Ardlie, K, Khan, O, Cree, BAC, Hauser, SL, Oksenberg, JR, Hafler, DA & Kelly, M 2005, 'A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility', Nature Genetics, vol. 37, no. 10, pp. 1113-8. https://doi.org/10.1038/ng1646

TY - JOUR

T1 - A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

AU - Reich, David

AU - Patterson, Nick

AU - De Jager, Philip L

AU - McDonald, Gavin J

AU - Waliszewska, Alicja

AU - Tandon, Arti

AU - Lincoln, Robin R

AU - DeLoa, Cari

AU - Fruhan, Scott A

AU - Cabre, Philippe

AU - Bera, Odile

AU - Semana, Gilbert

AU - Kelly, M Ann

AU - Francis, David A

AU - Ardlie, Kristin

AU - Khan, Omar

AU - Cree, Bruce A C

AU - Hauser, Stephen L

AU - Oksenberg, Jorge R

AU - Hafler, David A

AU - Kelly, Marilyn

PY - 2005

Y1 - 2005

N2 - Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.

AB - Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.

U2 - 10.1038/ng1646

DO - 10.1038/ng1646

M3 - Article

C2 - 16186815

SN - 1061-4036

VL - 37

SP - 1113

EP - 1118

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

Abstract

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