A water-solube azobenzene cross-linker for photocontrol conformation

ZH Zhang; DC Burns; JR Kumita; Oliver Smart; GA Woolley

doi:10.1021/bc0340161

A water-solube azobenzene cross-linker for photocontrol conformation

ZH Zhang, DC Burns, JR Kumita, Oliver Smart, GA Woolley

Biosciences

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59 Citations (Scopus)

Abstract

We have designed and synthesized a water-soluble, sulfonated version of an azobenzene-based thiol-reactive cross-linker that can be introduced into peptides and proteins and act as a conformational photoswitch. The sulfonated compound is shown to effect a similar degree of conformational control on a model peptide helix system, as its nonsulfonated counterpart but can be introduced without the need for any organic cosolvent. The sulfonated azobenzene cross-linker thus expands the range of proteins to which photocontrol can be applied.

Original language	English
Pages (from-to)	824-829
Number of pages	6
Journal	Bioconjugate Chemistry
Volume	14
DOIs	https://doi.org/10.1021/bc0340161
Publication status	Published - 16 Jul 2003

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abstract = "We have designed and synthesized a water-soluble, sulfonated version of an azobenzene-based thiol-reactive cross-linker that can be introduced into peptides and proteins and act as a conformational photoswitch. The sulfonated compound is shown to effect a similar degree of conformational control on a model peptide helix system, as its nonsulfonated counterpart but can be introduced without the need for any organic cosolvent. The sulfonated azobenzene cross-linker thus expands the range of proteins to which photocontrol can be applied.",

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AU - Burns, DC

AU - Kumita, JR

AU - Smart, Oliver

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A water-solube azobenzene cross-linker for photocontrol conformation

Abstract

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