Abstract
We have designed and synthesized a water-soluble, sulfonated version of an azobenzene-based thiol-reactive cross-linker that can be introduced into peptides and proteins and act as a conformational photoswitch. The sulfonated compound is shown to effect a similar degree of conformational control on a model peptide helix system, as its nonsulfonated counterpart but can be introduced without the need for any organic cosolvent. The sulfonated azobenzene cross-linker thus expands the range of proteins to which photocontrol can be applied.
Original language | English |
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Pages (from-to) | 824-829 |
Number of pages | 6 |
Journal | Bioconjugate Chemistry |
Volume | 14 |
DOIs | |
Publication status | Published - 16 Jul 2003 |