A water-solube azobenzene cross-linker for photocontrol conformation
Research output: Contribution to journal › Article
Colleges, School and Institutes
We have designed and synthesized a water-soluble, sulfonated version of an azobenzene-based thiol-reactive cross-linker that can be introduced into peptides and proteins and act as a conformational photoswitch. The sulfonated compound is shown to effect a similar degree of conformational control on a model peptide helix system, as its nonsulfonated counterpart but can be introduced without the need for any organic cosolvent. The sulfonated azobenzene cross-linker thus expands the range of proteins to which photocontrol can be applied.
|Number of pages||6|
|Publication status||Published - 16 Jul 2003|