A water-solube azobenzene cross-linker for photocontrol conformation

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Colleges, School and Institutes


We have designed and synthesized a water-soluble, sulfonated version of an azobenzene-based thiol-reactive cross-linker that can be introduced into peptides and proteins and act as a conformational photoswitch. The sulfonated compound is shown to effect a similar degree of conformational control on a model peptide helix system, as its nonsulfonated counterpart but can be introduced without the need for any organic cosolvent. The sulfonated azobenzene cross-linker thus expands the range of proteins to which photocontrol can be applied.


Original languageEnglish
Pages (from-to)824-829
Number of pages6
JournalBioconjugate Chemistry
Publication statusPublished - 16 Jul 2003