A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease

Carl Clarke, Joanne Stockton, Karen Morrison, Catriona Moorby

    Research output: Contribution to journalArticle

    200 Citations (Scopus)

    Abstract

    A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan. However, the second stage genotyping array, the ImmunoChip, included a larger set of 1,920 SNPs selected on the basis of the GWA analysis. Here, we analyzed this set of 1,920 SNPs, and we identified five additional PD risk loci (combined p
    Original languageEnglish
    Pages (from-to)e1002142
    JournalPLoS Genetics
    Volume7
    Issue number6
    Publication statusPublished - 1 Jan 2011

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