A Toll-receptor map underlies structural brain plasticity

Research output: Contribution to journalArticlepeer-review

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A Toll-receptor map underlies structural brain plasticity. / Li, Guiyi; Forero, Manuel G.; Wentzell, Jill; Durmus, Ilgim ; Wolf, Reinhard; Anthoney, Niki; Parker, Mieczyslaw; Jiang, Ruiying; Hasenauer, Jacob; Strausfeld, Nicholas James ; Heisenberg, Martin ; Hidalgo, Alicia.

In: eLife, Vol. 9, e52743, 18.02.2020, p. 1-32.

Research output: Contribution to journalArticlepeer-review

Harvard

Li, G, Forero, MG, Wentzell, J, Durmus, I, Wolf, R, Anthoney, N, Parker, M, Jiang, R, Hasenauer, J, Strausfeld, NJ, Heisenberg, M & Hidalgo, A 2020, 'A Toll-receptor map underlies structural brain plasticity', eLife, vol. 9, e52743, pp. 1-32. https://doi.org/10.7554/eLife.52743

APA

Li, G., Forero, M. G., Wentzell, J., Durmus, I., Wolf, R., Anthoney, N., Parker, M., Jiang, R., Hasenauer, J., Strausfeld, N. J., Heisenberg, M., & Hidalgo, A. (2020). A Toll-receptor map underlies structural brain plasticity. eLife, 9, 1-32. [e52743]. https://doi.org/10.7554/eLife.52743

Vancouver

Author

Li, Guiyi ; Forero, Manuel G. ; Wentzell, Jill ; Durmus, Ilgim ; Wolf, Reinhard ; Anthoney, Niki ; Parker, Mieczyslaw ; Jiang, Ruiying ; Hasenauer, Jacob ; Strausfeld, Nicholas James ; Heisenberg, Martin ; Hidalgo, Alicia. / A Toll-receptor map underlies structural brain plasticity. In: eLife. 2020 ; Vol. 9. pp. 1-32.

Bibtex

@article{721251fd85e54246b6a8945af61836d0,
title = "A Toll-receptor map underlies structural brain plasticity",
abstract = "Experience alters brain structure, but the underlying mechanism remained unknown. Structural plasticity reveals that brain function is encoded in generative changes to cells that compete with destructive processes driving neurodegeneration. At an adult critical period, experience increases fiber number and brain size in Drosophila. Here, we asked if Toll receptors are involved. Tolls demarcate a map of brain anatomical domains. Focusing on Toll-2, loss of function caused apoptosis, neurite atrophy and impaired behaviour. Toll-2 gain of function and neuronal activity at the critical period increased cell number. Toll-2 induced cycling of adult progenitor cells via a novel pathway, that antagonized MyD88-dependent quiescence, and engaged Weckle and Yorkie downstream. Constant knock-down of multiple Tolls synergistically reduced brain size. Conditional over-expression of Toll-2 and wek at the adult critical period increased brain size. Through their topographic distribution, Toll receptors regulate neuronal number and brain size, modulating structural plasticity in the adult brain.",
keywords = "D. melanogaster, Drosophila, MyD88, Toll, Yorkie, adul progenitor cells, adult neurogenesis, brain, critical period, neurodegeneration, neuron, neuronal activity, neuroscience, quiescence, structural plasticity, wek",
author = "Guiyi Li and Forero, {Manuel G.} and Jill Wentzell and Ilgim Durmus and Reinhard Wolf and Niki Anthoney and Mieczyslaw Parker and Ruiying Jiang and Jacob Hasenauer and Strausfeld, {Nicholas James} and Martin Heisenberg and Alicia Hidalgo",
note = "Selected for dedicated eLife Digest article {"}How experience shapes the brain{"}. Link given below.; How experience shapes the brain ; Conference date: 17-03-2020 Through 17-03-2020",
year = "2020",
month = feb,
day = "18",
doi = "10.7554/eLife.52743",
language = "English",
volume = "9",
pages = "1--32",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
url = "https://elifesciences.org/digests/52743/how-experience-shapes-the-brain",

}

RIS

TY - JOUR

T1 - A Toll-receptor map underlies structural brain plasticity

AU - Li, Guiyi

AU - Forero, Manuel G.

AU - Wentzell, Jill

AU - Durmus, Ilgim

AU - Wolf, Reinhard

AU - Anthoney, Niki

AU - Parker, Mieczyslaw

AU - Jiang, Ruiying

AU - Hasenauer, Jacob

AU - Strausfeld, Nicholas James

AU - Heisenberg, Martin

AU - Hidalgo, Alicia

N1 - Selected for dedicated eLife Digest article "How experience shapes the brain". Link given below.

PY - 2020/2/18

Y1 - 2020/2/18

N2 - Experience alters brain structure, but the underlying mechanism remained unknown. Structural plasticity reveals that brain function is encoded in generative changes to cells that compete with destructive processes driving neurodegeneration. At an adult critical period, experience increases fiber number and brain size in Drosophila. Here, we asked if Toll receptors are involved. Tolls demarcate a map of brain anatomical domains. Focusing on Toll-2, loss of function caused apoptosis, neurite atrophy and impaired behaviour. Toll-2 gain of function and neuronal activity at the critical period increased cell number. Toll-2 induced cycling of adult progenitor cells via a novel pathway, that antagonized MyD88-dependent quiescence, and engaged Weckle and Yorkie downstream. Constant knock-down of multiple Tolls synergistically reduced brain size. Conditional over-expression of Toll-2 and wek at the adult critical period increased brain size. Through their topographic distribution, Toll receptors regulate neuronal number and brain size, modulating structural plasticity in the adult brain.

AB - Experience alters brain structure, but the underlying mechanism remained unknown. Structural plasticity reveals that brain function is encoded in generative changes to cells that compete with destructive processes driving neurodegeneration. At an adult critical period, experience increases fiber number and brain size in Drosophila. Here, we asked if Toll receptors are involved. Tolls demarcate a map of brain anatomical domains. Focusing on Toll-2, loss of function caused apoptosis, neurite atrophy and impaired behaviour. Toll-2 gain of function and neuronal activity at the critical period increased cell number. Toll-2 induced cycling of adult progenitor cells via a novel pathway, that antagonized MyD88-dependent quiescence, and engaged Weckle and Yorkie downstream. Constant knock-down of multiple Tolls synergistically reduced brain size. Conditional over-expression of Toll-2 and wek at the adult critical period increased brain size. Through their topographic distribution, Toll receptors regulate neuronal number and brain size, modulating structural plasticity in the adult brain.

KW - D. melanogaster

KW - Drosophila

KW - MyD88

KW - Toll

KW - Yorkie

KW - adul progenitor cells

KW - adult neurogenesis

KW - brain

KW - critical period

KW - neurodegeneration

KW - neuron

KW - neuronal activity

KW - neuroscience

KW - quiescence

KW - structural plasticity

KW - wek

U2 - 10.7554/eLife.52743

DO - 10.7554/eLife.52743

M3 - Article

C2 - 32066523

VL - 9

SP - 1

EP - 32

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e52743

T2 - How experience shapes the brain

Y2 - 17 March 2020 through 17 March 2020

ER -