TY - JOUR
T1 - A theory of germinal center B cell selection, division, and exit
AU - Meyer-Hermann, Michael
AU - Mohr, Elodie
AU - Pelletier, Nadége
AU - Zhang, Yang
AU - Victora, Gabriel D
AU - Toellner, Kai-Michael
N1 - Copyright © 2012 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2012/7/26
Y1 - 2012/7/26
N2 - High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments. These have revealed cell migration patterns, asymmetric cell divisions, and cell-cell interaction characteristics, used here to develop a theory of germinal center B cell selection, division, and exit (the LEDA model). According to this model, B cells selected by T follicular helper cells on the basis of successful antigen processing always return to the dark zone for asymmetric division, and acquired antigen is inherited by one daughter cell only. Antigen-retaining B cells differentiate to plasma cells and leave the germinal center through the dark zone. This theory has implications for the functioning of germinal centers because compared to previous models, high-affinity antibodies appear one day earlier and the amount of derived plasma cells is considerably larger.
AB - High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments. These have revealed cell migration patterns, asymmetric cell divisions, and cell-cell interaction characteristics, used here to develop a theory of germinal center B cell selection, division, and exit (the LEDA model). According to this model, B cells selected by T follicular helper cells on the basis of successful antigen processing always return to the dark zone for asymmetric division, and acquired antigen is inherited by one daughter cell only. Antigen-retaining B cells differentiate to plasma cells and leave the germinal center through the dark zone. This theory has implications for the functioning of germinal centers because compared to previous models, high-affinity antibodies appear one day earlier and the amount of derived plasma cells is considerably larger.
U2 - 10.1016/j.celrep.2012.05.010
DO - 10.1016/j.celrep.2012.05.010
M3 - Article
C2 - 22840406
SN - 2211-1247
VL - 2
SP - 162
EP - 174
JO - Cell Reports
JF - Cell Reports
IS - 1
ER -