A theory of germinal center B cell selection, division, and exit

Research output: Contribution to journalArticlepeer-review

Authors

  • Michael Meyer-Hermann
  • Nadége Pelletier
  • Gabriel D Victora

Colleges, School and Institutes

Abstract

High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments. These have revealed cell migration patterns, asymmetric cell divisions, and cell-cell interaction characteristics, used here to develop a theory of germinal center B cell selection, division, and exit (the LEDA model). According to this model, B cells selected by T follicular helper cells on the basis of successful antigen processing always return to the dark zone for asymmetric division, and acquired antigen is inherited by one daughter cell only. Antigen-retaining B cells differentiate to plasma cells and leave the germinal center through the dark zone. This theory has implications for the functioning of germinal centers because compared to previous models, high-affinity antibodies appear one day earlier and the amount of derived plasma cells is considerably larger.

Details

Original languageEnglish
Pages (from-to)162-74
Number of pages13
JournalCell Reports
Volume2
Issue number1
Publication statusPublished - 26 Jul 2012