A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders

Ruth C.M. Philip; Maria R. Dauvermann; Heather C. Whalley; Katie Baynham; Stephen M. Lawrie; Andrew C. Stanfield

doi:10.1016/j.neubiorev.2011.10.008

A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders

Ruth C.M. Philip, Maria R. Dauvermann, Heather C. Whalley, Katie Baynham, Stephen M. Lawrie, Andrew C. Stanfield^*

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Review article › peer-review

202 Citations (Scopus)

Abstract

Recent years have seen a rapid increase in the investigation of autism spectrum disorders (ASD) through the use of functional magnetic resonance imaging (fMRI). We carried out a systematic review and ALE meta-analysis of fMRI studies of ASD. A disturbance to the function of social brain regions is among the most well replicated finding. Differences in social brain activation may relate to a lack of preference for social stimuli as opposed to a primary dysfunction of these regions. Increasing evidence points towards a lack of effective integration of distributed functional brain regions and disruptions in the subtle modulation of brain function in relation to changing task demands in ASD. Limitations of the literature to date include the use of small sample sizes and the restriction of investigation to primarily high functioning males with autism.

Original language	English
Pages (from-to)	901-942
Number of pages	42
Journal	Neuroscience and biobehavioral reviews
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.neubiorev.2011.10.008 https://doi.org/10.1016/j.neubiorev.2011.10.008
Publication status	Published - 1 Feb 2012

Bibliographical note

Funding Information:
The authors report no conflicts of interest. RCMP and KB were funded by a Medical Research Scotland grant awarded to ACS. HCW is supported by a Dorothy Hodgkin Fellowship from the Royal Society . During this work ACS was supported by a Wellcome Trust Clinical Research Training Fellowship . Further support for this study came from the Patrick Wild Centre .

Keywords

Autism spectrum disorders
Functional magnetic resonance imaging
Meta-analysis
Systematic review

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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abstract = "Recent years have seen a rapid increase in the investigation of autism spectrum disorders (ASD) through the use of functional magnetic resonance imaging (fMRI). We carried out a systematic review and ALE meta-analysis of fMRI studies of ASD. A disturbance to the function of social brain regions is among the most well replicated finding. Differences in social brain activation may relate to a lack of preference for social stimuli as opposed to a primary dysfunction of these regions. Increasing evidence points towards a lack of effective integration of distributed functional brain regions and disruptions in the subtle modulation of brain function in relation to changing task demands in ASD. Limitations of the literature to date include the use of small sample sizes and the restriction of investigation to primarily high functioning males with autism.",

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AU - Lawrie, Stephen M.

AU - Stanfield, Andrew C.

N1 - Funding Information: The authors report no conflicts of interest. RCMP and KB were funded by a Medical Research Scotland grant awarded to ACS. HCW is supported by a Dorothy Hodgkin Fellowship from the Royal Society . During this work ACS was supported by a Wellcome Trust Clinical Research Training Fellowship . Further support for this study came from the Patrick Wild Centre .

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A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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