A synthetic alternative to the Type II Intramolecular 4+3 Cycloaddition Reaction
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Colleges, School and Institutes
Oxyallyl cations generated in situ from dihaloketones have been found to undergo the Favorskii rearrangement in preference to an intramolecular Type-II 4 + 3 cycloaddition reaction in trifluoroethanol and hexafluoropropan-2-ol solvents, generating acrylate esters with high cis selectivity. A synthetic alternative to the intramolecular Type-II 4 + 3 cycloaddition has been developed on the basis of intramolecular enolate alkylation to close a 7-membered ring with an exocyclic double bond.
|Number of pages||4|
|Journal||The Journal of Organic Chemistry|
|Publication status||Published - 1 Jan 2003|